Network pharmacology and molecular dynamics study of the effect of the Astragalus-Coptis drug pair on diabetic kidney disease

Table 3 Information on the differential gene expression analysis identified from the Gene Expression Omnibus dataset

Gene symbol	Protein name	Log2FC	P value	Change
PLCE1	Phospholipase C epsilon 1	3.980421	0.00000765	Upregulated
CLIC5	Chloride intracellular channel 5	4.380969	0.00001522	Upregulated
PTPRO	Protein tyrosine phosphatase receptor type O	3.922249	0.00001810	Upregulated
HSPA12A	Heat shock protein family A (Hsp70) member 12A	4.194141	0.00001836	Upregulated
AIF1	Allograft inflammatory Factor 1	3.616273	0.00002007	Upregulated
GMDS	GDP-mannose 4,6-dehydratase	3.900218	0.00002555	Upregulated
SEMA5A	Semaphorin 5A	3.956868	0.00002673	Upregulated
CEP152	Centrosomal protein 152	4.004339	0.00002683	Downregulated
FOXC1	Forkhead Box C1	3.505715	0.00003095	Upregulated
MME	Membrane metalloendopeptidase	3.837958	0.00003666	Upregulated
FGF1	Fibroblast growth Factor 1	3.743398	0.00003695	Upregulated
TNNC1	Troponin C1, slow skeletal and cardiac type	3.602037	0.00004852	Upregulated
CYP2C8	Cytochrome P450 family 2 subfamily C member 8	-3.55671	0.00004895	Downregulated
THBS1	Thrombospondin 1	3.170090	0.00005034	Upregulated
VEGFA	Vascular endothelial growth Factor A	4.261645	0.00005391	Upregulated
LUNAR1	Leukemia-associated noncoding IGF1R activator RNA 1	3.265115	0.00005733	Downregulated
HOXD1	Homeobox D1	3.812893	0.00005999	Upregulated
BMP2	bone morphogenetic protein 2	3.115485	0.00006297	Upregulated
IQGAP2	IQ motif containing GTPase activating protein 2	2.540433	0.00006536	Upregulated
ST3GAL6	ST3 beta-galactoside alpha-2,3-sialyltransferase 6	2.858100	0.00006870	Upregulated
THSD7A	Thrombospondin type 1 domain containing 7A	2.581030	0.00006966	Upregulated
F2R	Coagulation factor II thrombin receptor	2.809148	0.00007121	Upregulated
SLC9A1	Solute carrier family 9 member A1	4.330925	0.00007424	Downregulated
ADORA2B	Adenosine A2b receptor	2.582378	0.00008127	Downregulated
FAM153A	Family with sequence similarity 153 member A	3.774375	0.00009200	Upregulated
ITGB1	Integrin subunit beta 1	3.774328	0.00009284	Downregulated
CDS1	CDP-diacylglycerol synthase 1	2.695287	0.00009577	Upregulated
EGR2	Early growth response 2	3.580285	0.00010401	Downregulated
PLA2R1	Phospholipase A2 receptor 1	3.485108	0.00010718	Upregulated
GAS1	Growth arrest specific 1	3.659052	0.00010882	Upregulated
TYRO3	TYRO3 protein tyrosine kinase	2.854082	0.00011003	Upregulated
LOC101929500	Uncharacterized LOC101929500	2.664931	0.00011229	Upregulated
F3	Coagulation factor III, tissue factor	3.035691	0.00011752	Upregulated
XPNPEP2	X-prolyl aminopeptidase 2	3.454828	0.00013038	Downregulated
FUT6	Fucosyltransferase 6	3.357247	0.00013492	Downregulated
LCN1	Lipocalin 1	2.654097	0.00014868	Downregulated
C1orf21	Chromosome 1 open reading frame 21	2.655885	0.00015593	Upregulated
LOC103344931	Uncharacterized LOC103344931	2.423861	0.00015641	Upregulated
FRY	FRY microtubule binding protein	2.922064	0.00016127	Upregulated
POU2F2	POU class 2 homeobox 2	-2.51972	0.00016162	Downregulated
VEGFA	Vascular endothelial growth Factor A	2.860180	0.00016446	Upregulated
CHRNE	Cholinergic receptor nicotinic epsilon subunit	2.954435	0.00016654	Downregulated
TUBB4A	Tubulin beta 4A class IVa	3.908527	0.00016713	Downregulated
MGAT5	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	2.568678	0.00017864	Upregulated
PTPRD	Protein tyrosine phosphatase receptor type D	3.052249	0.00018095	Upregulated
HYAL1	Hyaluronidase 1	-2.217640	0.00018409	Downregulated
DPYSL3	Dihydropyrimidinase like 3	3.782204	0.00018554	Upregulated
UGT2B17	UDP glucuronosyltransferase family 2 member B17	2.604504	0.00018633	Downregulated
PAM	Peptidylglycine alpha-amidating monooxygenase	2.25575	0.00018848	Upregulated
RFC4	Replication Factor C subunit 4	3.094109	0.00020080	Downregulated