Network pharmacology and molecular dynamics study of the effect of the Astragalus-Coptis drug pair on diabetic kidney disease

Table 2 Active ingredients of the Astragalus-Coptis drug pair

TCM	Serial number	MOL ID	Ingredient	OB (%)	DL
Astragalus membranaceus	HQ1	MOL000379	9,10-dimethoxypterocarpan-3-O-β-D-glucoside	36.74	0.92
	HQ2	MOL000387	Bifendate	31.10	0.67
	HQ3	MOL000442	1,7-Dihydroxy-3,9-dimethoxy pterocarpene	39.05	0.48
	HQ4	MOL000371	3,9-di-O-methylnissolin	53.74	0.48
	HQ5	MOL000380	(6aR,11aR)-9,10-dimethoxy-6a,11a-dihydro-6H-benzofurano[3,2-c]chromen-3-ol	64.26	0.42
	HQ6	MOL000354	Isorhamnetin	49.60	0.31
	HQ7	MOL000378	7-O-methylisomucronulatol	74.69	0.30
	HQ8	MOL000398	Isoflavanone	109.99	0.03
	HQ9	MOL000239	Jaranol	50.83	0.29
	HQ10	MOL000098	Quercetin	46.43	0.28
	HQ11	MOL000438	(3R)-3-(2-hydroxy-3,4-dimethoxyphenyl)chroman-7-ol	67.67	0.26
	HQ12	MOL000417	Calycosin	47.75	0.24
	HQ13	MOL000422	Kaempferol	41.88	0.24
	HQ14	MOL000392	Formononetin	69.67	0.21
Coptis chinensis Franch	HL1	MOL002903	(R)-Canadine	55.37	0.77
	HL2	MOL001454	Berberine	36.86	0.78
	HL3	MOL002894	Berberrubine	35.74	0.73
	HL4	MOL002904	Berlambine	36.68	0.82
	HL5	MOL001458	Coptisine	30.67	0.86
	HL6	MOL002907	Corchoroside A_qt	104.95	0.78
	HL7	MOL002897	Epiberberine	43.09	0.78
	HL8	MOL000622	Magnograndiolide	63.71	0.19
	HL9	MOL008647	Moupinamide	86.71	0.26
	HL10	MOL013352	Obacunone	43.29	0.77
	HL11	MOL000785	Palmatine	64.60	0.65
	HL12	MOL000098	Quercetin	46.43	0.28
	HL13	MOL002668	Worenine	45.83	0.87

DL: Drug-likeness; MOL: Molecule; OB: Oral bioavailability; TCM: Traditional Chinese medicine.