Subclinical impairment of left ventricular myocardium function in type 2 diabetes mellitus patients with or without hypertension

Table 1 Clinical parameters of patients with healthy subjects, type 2 diabetes mellitus patients and type 2 diabetes mellitus patients with hypertension

Clinical parameters	Healthy subjects (n = 101)	T2DM (n = 97)	T2DM + HP (n = 70)	P value
Age, yr	48.06 ± 9.90	49.04 ± 12.80	52.00 ± 11.50	0.068
Male, n (%)	48 (48)	61 (63)	39 (56)	0.094
Hight, cm	165.10 ± 7.50	166.87 ± 9.25	164.66 ± 7.53	0.199
Wight, kg	64.14 ± 10.58	72.50 ± 15.341	72.23 ± 13.801	< 0.001
BMI, kg/m2	23.44 ± 2.84	25.85 ± 3.901	26.51 ± 4.021	< 0.001
BSA, m2	1.68 ± 0.17	1.79 ± 0.241	1.78 ± 0.211	< 0.001
SBP, mmHg	123.26 ± 10.82	127.65 ± 14.701	137.07 ± 17.341,2	< 0.001
DBP, mmHg	77.85 ± 7.65	79.25 ± 10.59	86.64 ± 10.201,2	< 0.001
HR, bpm	69.85 ± 9.76	75.22 ± 9.601	79.10 ± 12.721,2	<0.001
FPG, mmol/L	4.95 (4.59, 5.25)	10.53 (7.87, 14.07)1	8.91 (7.57, 10.97)1	< 0.001
HbA1c, %	5.45 ± 0.38	9.73 ± 2.271	8.85 ± 2.491,2	< 0.001
TC, mmol/L	4.54 ± 0.85	4.37 ± 0.90	4.70 ± 1.14	0.102
TG, mmol/L	1.21 (0.88,1.78)	1.53 (0.97, 2.15)1	2.00 (1.38, 2.83)1,2	< 0.001
HDL-C, mmol/L	1.27 ± 0.30	1.09 ± 0.291	1.04 ± 0.281	< 0.001
LDL-C, mmol/L	2.68 ± 0.70	2.65 ± 0.79	2.81 ± 0.99	0.556
LPA, g/L	0.17 (0.11, 0.28)	0.14 (0.06, 0.24)	0.14 (0.08, 0.25)	0.231
BUN, mmol/L	4.75 (3.60, 5.70)	5.50 (4.60, 6.30)1	5.50 (4.50, 7.40)1	0.001
SCR, μmol/L	61.00 (55.00, 76.00)	59.00 (49.30, 71.10)	64.00 (54.00, 87.00)2	0.030
Medication, n (%)
ACEI/ARB	-	-	32 (46)
Calcium channel blocker	-	-	37 (53)
β-blocker	-	-	4 (6)
SGLT-2 inhibitor	-	18 (19)	28 (40)
Metformin	-	59 (61)	38 (54)
Insulin	-	55 (57)	35 (50)

¹Significantly different (P < 0.05) between type 2 diabetes mellitus (T2DM) or T2DM + hypertension (HP) patients and healthy subjects.

²Significantly different (P < 0.05) between T2DM + HP patients and T2DM patients.

BMI: Body mass index; BSA: Body surface area; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; HR: Heart rate; FPG: Fasting plasma glucose; HbA1c: Glycated haemoglobin; TC: Total cholesterol; TG: Triglyceride; HDL-C: High-density lipoprotein; LDL-C: Low-density lipoprotein; BUN: Blood urea nitrogen; SCR: Serum creatinine.