Correlation between cerebral neurotransmitters levels by proton magnetic resonance spectroscopy and HbA1c in patients with type 2 diabetes

Table 3 Correlation between variables and hemoglobin A1c by Spearman correlation analysis

Variables	r	P value
Age (yr)	-0.063	0.474
Sex (male/female)	-0.082	0.351
Diabetes duration (yr)	-0.150	0.090
Height (cm)	0.113	0.201
Weight (cm)	0.057	0.518
BMI (kg/m2)	-0.046	0.605
Neck line (cm)	-0.087	0.327
Waist line (cm)	-0.091	0.303
Hip line (cm)	-0.135	0.126
WHR	0.011	0.897
SBP (mmHg)	0.028	0.753
DBP (mmHg)	0.093	0.294
mALB (g/L)	0.215	0.014
TC (mmol/L)	0.154	0.081
TG (mmol/L)	-0.036	0.686
HDL-C (mmol/L)	-0.096	0.275
LDL-C (mmol/L)	0.216	0.014
HOMA-IR	0.345	< 0.001
HOMA-β	-0.316	< 0.001
Complicated with hypertension (%)	-0.015	0.868
Complicated with CHD (%)	-0.016	0.860
NAA/Cr (left hippocampus)	0.090	0.310
Cho/Cr (left hippocampus)	0.168	0.056
NAA/Cho (left hippocampus)	-0.061	0.502
NAA/Cr (left brainstem area)	0.257	0.007
Cho/Cr (left brainstem area)	0.128	0.182
NAA/Cho (left brainstem area)	0.166	0.081

BMI: Body mass index; WHR: Waist-to-hip ratio; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; mALB: Microalbumin; TC: Total cholesterol; TG: Triglyceride; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; HOMA-IR: Homeostasis model assessment of insulin resistance; HOMA-β: Homeostasis model assessment of beta cell function; CHD: Coronary heart disease; NAA: N-acetylaspartate; Cho: Choline; Cr: Creatine.