Correlation between cerebral neurotransmitters levels by proton magnetic resonance spectroscopy and HbA1c in patients with type 2 diabetes

Table 2 Neurotransmitter levels of participates by quartiles of hemoglobin A1c

Neurotransmitters	HbA1c quartiles				P value
	Q1 (< 7.875), n = 32	Q2 (7.875-9.050), n = 33	Q3 (9.050-11.200), n = 32	Q4 (≥ 11.200), n = 33
NAA/Cr (left hippocampus)	1.43 (0.55, 2.58)	0.74 (0.36, 1.72)	1.02 (0.80, 1.99)	1.60 (0.78, 3.10)	0.082
Cho/Cr (left hippocampus)	0.75 (0.42, 1.32)	0.96 (0.51, 1.63)	1.10 (0.29, 2.28)	1.36 (0.68, 2.27)	0.277
NAA/Cho (left hippocampus)	1.27 (0.62, 4.48)	1.02 (0.42, 1.61)	0.83 (0.44, 2.88)	0.95 (0.47, 1.81)	0.529
NAA/Cr (left brainstem area)	0.84 (0.33, 1.58)	1.17 (0.63, 2.11)	0.92 (0.30, 1.94)	1.72 (1.04, 3.48)	0.024
Cho/Cr (left brainstem area)	1.13 (0.62, 2.04)	1.55 (0.76, 3.44)	1.54 (1.28, 2.82)	1.74 (0.70, 2.49)	0.299
NAA/Cho (left brainstem area)	0.91 (0.32, 1.64)	0.71 (0.47, 1.06)	0.69 (0.31, 1.11)	1.41 (0.82, 2.05)	0.013

HbA1c: Hemoglobin A1c; NAA: N-acetylaspartate; Cr: Creatine; Cho: Choline.