Metformin-associated lactic acidosis: A mini review of pathophysiology, diagnosis and management in critically ill patients

doi:10.4239/wjd.v15.i6.1178

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jun 15, 2024; 15(6): 1178-1186
Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1178

Table 2 Risk factors for metformin-associated lactic acidosis

Risk factors	Mechanism
Kidney failure (any cause)	Reduced renal elimination of metformin[45]
Cimetidine	Reduced renal elimination of metformin[51]
Ribociclib	Reduced renal elimination of metformin[52]
Excessive alcohol consumption	Ethanol oxidation consumes nicotinamide adenine dinucleotides that are also required for lactate metabolism[50]

Citation: See KC. Metformin-associated lactic acidosis: A mini review of pathophysiology, diagnosis and management in critically ill patients. World J Diabetes 2024; 15(6): 1178-1186
URL: https://www.wjgnet.com/1948-9358/full/v15/i6/1178.htm
DOI: https://dx.doi.org/10.4239/wjd.v15.i6.1178