Monogenic diabetes in children: An underdiagnosed and poorly managed clinical dilemma

Table 2 Clinical conditions suggestive of neonatal diabetes mellitus and for ordering genetic analysis

Rank	Clinical or laboratory context
1	Infant before 6 months of age with plasma glucoses persistently > 250 mg/dL (13.9 mmol/L) without an alternative etiology
2	Hyperglycemia persisting after seven to ten days of birth
3	Infants with extreme hyperglycemia i.e., plasma glucose > 1000 mg/dL (55.6 mmol/L)
4	Infants with diabetes diagnosed between 6 and 12 months, especially in those without islet autoantibodies or who have other features suggestive of a monogenic cause
5	Infants with transient diabetes mellitus1

¹Median age when treatment is not required is 12-14 wk in 6q24 anomalies.