Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation

Figure 1 Expression of synaptotagmins family members in diabetic retinopathy. A: The expression of synaptotagmins 1 (SYT1)-SYT17 was analyzed to identify differentially expressed proteins; B: The expression of SYT2, SYT3, SYT4, SYT7, SYT11, and SYT13 was measured via reverse transcriptase-polymerase chain reaction; C and D: The expression of SYT2, SYT3, SYT4, SYT7, SYT11, and SYT13 in ARPE-19 cells (C) induced by high glucose was detected by Western blot, and the expression in the retinas of diabetic retinopathy model mice (D) induced by streptozotocin was detected by Western blot. ^aP < 0.01, ^bP < 0.001, vs the normal group, control group, NC group. SYT: Synaptotagmins; DR: Diabetic retinopathy.