Enzyme-linked immunosorbent assay of 3 Screen Islet Cell Autoantibody in patients with autoimmune thyroid disease

Figure 3 The distribution of autoantibodies to glutamic acid decarboxylase, insulinoma-associated antigen-2, and zinc transporter 8 in 3 Screen Islet Cell Autoantibody-positive and negative patients in each group. A: Autoimmune thyroid disease (AITD) with type 1 diabetes (T1D), B: AITD with type 2 diabetes (T2D), C: AITD without diabetes. Among the 3 Screen Islet Cell Autoantibody (3 Screen ICA)-positive patients, there was a significantly higher proportion of individual with multiple autoantibodies in AITD with T1D compared to those without diabetes (P < 0.05). However, this proportion was similar to that in AITD patients with T2D. Furthermore, 1.3% of 3 Screen ICA-negative patients were solely positive for insulinoma-associated antigen-2 autoantibodies or zinc transporter 8 autoantibodies in AITD patients with T2D and AITD patients without diabetes. 3 Screen ICA: 3 Screen Islet Cell Autoantibody; GADA: Glutamic acid decarboxylase 65 autoantibodies; IA-2A: Insulinoma-associated antigen-2 autoantibodies; ZnT8A: Zinc transporter 8 autoantibodies.