Efficacy of Huangma Ding or autologous platelet-rich gel for the diabetic lower extremity arterial disease patients with foot ulcers

Table 2 Changes in parameters after each treatment (mean ± SD)

Parameter	Group A	Group B	Group C	P value
FPG (mmol/L)	6.37 ± 1.43	6.40 ± 1.26	6.14 ± 1.20	0.553
White blood cells	8.84 ± 3.46	7.35 ± 1.741	5.83 ± 1.352	0.000
Neutrophils	6.38 ± 3.66	4.97 ± 2.001	3.10 ± 1.122	0.000
Uric acid (µmol/L)	298.74 ± 71.33	294.61 ± 72.68	282.76 ± 63.40	0.444
SBP (mmHg)	126.37 ± 9.39	123.07 ± 10.60	124.27 ± 11.15	0.272
DBP (mmHg)	75.23 ± 5.84	73.76 ± 6.50	73.91 ± 4.56	0.325
PCT (mmol/L)	0.72 ± 0.95	0.36 ± 0.451	0.05 ± 0.072	0.000
HbA1c (%)	6.74 ± 0.87	6.76 ± 0.72	6.81 ± 0.52	0.855
LDL (mmol/L)	2.29 ± 0.48	2.27 ± 0.47	2.44 ± 0.46	0.141
HDL (mmol/L)	0.83 ± 0.26	0.74 ± 0.24	0.77 ± 0.22	0.136
TG (mmol/L)	2.63 ± 0.70	2.51 ± 0.82	2.57 ± 0.56	0.683
TC (mmol/L)	4.47 ± 0.53	4.49 ± 0.70	4.43 ± 0.62	0.901
ABI	0.76 ± 0.09	0.79 ± 0.08	0.81 ± 0.082	0.032
TcPO2 (mmHg)	35.56 ± 10.13	46.32 ± 8.831	48.19 ± 8.352	0.000
Total amputations	1.23 ± 1.14	0.63 ± 0.631	0.16 ± 0.372	0.000
Mortality rate	4.84%	0.00%	0.00%	0.102
Cardiovascular event rate	8.06%	0.00%1	0.00%2	0.020
Hospitalization rate	62.90%	26.32%1	5.45%2	0.000
Reamputation rate	58.06%	28.95%1	1.82%2	0.000
Major amputation rate	69.35%	31.58%1	36.40%2	0.000
Minor amputation rate	53.23%	31.58%1	14.55%2	0.000
Heal rate	14.52%	65.79%1	89.09%2	0.000
Improve rate	85.48%	36.84%1	10.91%2	0.000
Ulcer area (cm2)	3.74 ± 2.04	2.68 ± 1.961	1.77 ± 1.212	0.000
Diabetic foot surgery class	3.01 ± 0.64	2.08 ± 0.921	1.49 ± 0.962	0.000

¹Group A vs group B: P < 0.05.

²Group A vs group C: P < 0.05.

FPG: Fasting blood glucose; HbA1c: Glycosylated hemoglobin; LDL: Low-density lipoprotein; HDL: High-density lipoprotein; TC: Total cholesterol; TG: Triglyceride; CCB: Calcium channel blocker; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; ABI: Ankle-brachial pressure; TcPO₂: Transcutaneous oxygen pressure; PCT: Procalcitonin.