Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina

Figure 4 High glucose combined with hypoxia up-regulated transcription and increased protein levels of receptor for activated C kinase 1 and protein kinase C-ε in adult retinal pigment epithelium cell line-19 cells. A and B: The protein levels of receptor for activated C kinase 1 (RACK1) and protein kinase C-ε (PKC- ε) in the adult retinal pigment epithelium cell line-19 (ARPE-19) cells of normal control and high glucose combined with hypoxia; C: The ratio of mRNA of RACK1 and PKC- ε in ARPE-19 cells. The results are expressed as the mean ± SD. ^aP < 0.05 vs control group. ^bP < 0.01 vs control group. NC: Normal control; Hg + Hypo: High glucose combined with hypoxia; RACK1: Receptor for activated C kinase 1; PKC- ε: Protein kinase C-ε.