Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney, and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways

doi:10.4239/wjd.v15.i3.502

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World Journal of Diabetes

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Mar 15, 2024; 15(3): 502-518
Published online Mar 15, 2024. doi: 10.4239/wjd.v15.i3.502

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Figure 2 Pathological changes in kidneys were improved following Jianpi Gushen Huayu Decoction administration. A: Hematoxylin and eosin staining; B: Kidney damage score; C: Periodic acid Schiff staining; D: Glomerulosclerosis index, magnification × 100. ^bP < 0.01 as compared to the control group; ^cP < 0.05 as compared to the model group; ^dP < 0.01 as compared to the model group. JPGSL: Low-dose Jianpi Gushen Huayu Decoction; JPGSM: Medium-dose Jianpi Gushen Huayu Decoction; JPGSH: High-dose Jianpi Gushen Huayu Decoction; IRBE: Irbesartan.

Citation: Ma ZA, Wang LX, Zhang H, Li HZ, Dong L, Wang QH, Wang YS, Pan BC, Zhang SF, Cui HT, Lv SQ. Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney, and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways. World J Diabetes 2024; 15(3): 502-518
URL: https://www.wjgnet.com/1948-9358/full/v15/i3/502.htm
DOI: https://dx.doi.org/10.4239/wjd.v15.i3.502