Roles of fibroblast growth factors in the treatment of diabetes

Figure 1 Functions of fibroblast growth factor/fibroblast growth factor receptor signaling pathways in diabetes and diabetes-relative diseases. The mechanisms of action of fibroblast growth factors (FGFs) include suppression of hepatic glucose production and lipolysis in adipose tissues, activation of glucose-excited neurons, inhibition of renal injury and fibrosis, inhibition of insulin resistance, regulation of extracellular matrix components in cardiac fibroblasts, inhibition of cancer cell proliferation and migration, reduction of levels of fasting blood glucose and triglycerides, and promotion of the diabetic wound healing process. FGFR: Fibroblast growth factor receptor. All cartoons in this figure were prepared using Biorender.