Predictive value of angiopoietin-like protein 8 in metabolic dysfunction-associated fatty liver disease and its progression: A case-control study

Table 6 Receiver operating characteristic curve analysis of the predictive value of angiopoietin-like protein 8, triglyceride-glucose index, and its combination with triglyceride-glucose index for metabolic dysfunction-associated fatty liver disease and liver fibrosis

	AUC	95%CI	Cutoff	Sensitivity	Specificity	P valuea
Prediction of MAFLD
ANGPTL8	0.832	0.771-0.893	31.18	80.00	73.08	< 0.001
TyG index	0.773	0.701-0.845	9.155	67.5	80.77	< 0.001
ANGPTL8 + TyG index	0.886	0.846-0.941	0.546	75.5	85.9	< 0.001
Prediction of MAFLD with liver fibrosis
ANGPTL8	0.812	0.713-0.910	44.36	91.30	61.36	< 0.001
TyG index	0.688	0.553-0.822	9.925	60.87	75.44	< 0.001
ANGPTL8 + TyG index	0.835	0.735-0.935	0.3897	73.91	78.95	< 0.001

^aP < 0.05 is considered significant.

AUC: Area under the curve; MAFLD: Metabolic dysfunction-associated fatty liver disease; CI: Confidence interval; ANGPTL8: Angiopoietin-like protein 8; TyG index: Triglyceride-glucose index.