Metabolic disorders in prediabetes: From mechanisms to therapeutic management

Table 4 Dosage schedule for metformin for treating patients with prediabetes

Trial population	Prescribed dosage	Associated or not	Treatment cycle	Reversal rate	Ref.
Adolescents	1000 mg/d	Rosiglitazone (2 mg)	3.9 yr	80% improvement in glucose tolerance	Zinman et al[137]
Adolescents	1000 mg/d	No	6 months	45% increase in insulin sensitivity	Srinivasan et al[138]
Adults	850 mg/d	No	1 yr	7% reduction in the incidence of diabetes	Andreadis et al[139]
Adults	2000 mg/d	No	1 yr	Increased insulin sensitivity (P < 0.01)	Malin et al[134]
Adults	1500-2000 mg/d	Exenatide (10-20 μg/d)	1 yr	64% improvement in prediabetes remission rates	Tao et al[140]