Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling

Figure 7 Duodenal jejunal bypass surgery promotes hypothalamic neurogenesis in type 2 diabetes mellitus rats. A: Immunofluorescence analysis the expression of Ki67 (scale bar, 130 µm); B: The percentage of cells expressing Ki67; C: The percentage of cells expressing C-fos; D: Immunofluorescence analysis the expression of C-fos (scale bar, 120 µm); E: The quantitative real-time (qRT)-PCR results of C-fos expression; F: The qRT-PCR results of BDNF expression; G: Expression levels of C-fos and BDNF detected by Western blotting. The quantitative densitometric analysis of C-fos and BDNF. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. T2DM: Type 2 diabetes mellitus; DJB: Duodenal jejunal bypass.