Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling

Figure 3 Duodenal jejunal bypass surgery increases type 2 diabetes mellitus glucagon-like peptide 1 signals and enhances the expression of Nrf2/HO-1. A: Serum glucagon-like peptide 1 (GLP-1) secretion of rats in the three groups; B: The quantitative real-time PCR results of GLP-1 receptor (GLP-1R) expression; C: Expression levels of GLP-1R in the hypothalamus detected by Western blotting; D: The quantitative densitometric analysis of GLP-1R. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. T2DM: Type 2 diabetes mellitus; DJB: Duodenal jejunal bypass; GLP-1: Glucagon-like peptide 1; GLP-1R: Glucagon-like peptide 1 receptor.