Assessment of pathogenicity and functional characterization of APPL1 gene mutations in diabetic patients

Figure 5 Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1-related protein networks and the docking between adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 and insulin receptor. A The adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1)-related protein network. The degree of binding between proteins is indicated by the colors from yellow to orange on the nodes. The larger the node, the darker the color, and the higher the degree of binding to the APPL1 protein. The edge shows the association of protein-protein; B: The binding of the phosphotyrosine binding domain of APPL1 to insulin receptor proteins. Red is the phosphotyrosine binding domain, and blue is the insulin receptor protein.