Identification of hub genes associated with Helicobacter pylori infection and type 2 diabetes mellitus: A pilot bioinformatics study

Figure 4 Protein-protein interaction network showing interactions between common genes and identification of differentially expressed genes from this network. A: The protein-protein interaction (PPI) network of differentially expressed genes was constructed by Cytoscape software. The criteria of the PPI network were as follows: Confidence score ≥ 0.4 and a maximum number of interactions ≤ 5; B: The top module of the PPI network. MCODE score ≥ 3, 9 nodes and 21 edges; C: Construction of the PPI network among the 5 hub genes; D: Coexpression analysis of the 5 hub genes using STRING; E: The expression of 5 hub genes in clinical specimens by RT-qPCR analysis. ^aP < 0.05; ^bP < 0.01). T2DM: Type 2 diabetes mellitus; H. pylori: Helicobacter pylori.