Shikonin protects mitochondria through the NFAT5/AMPK pathway for the treatment of diabetic wounds

Figure 3 Effects of shikonin on blood glucose, wound healing, and NFAT5 expression in diabetic mice. A: Changes of blood glucose in mice (D3 vs D1, P < 0.05); B: Wound changes in shikonin group and blank group. Shikonin group after modeling: Day 1, day 3, day 6. Blank group after modeling: day 1, day 3, day 6; C: Wound area changing and wound healing time; D: The immunofluorescence expressions of NFAT5 protein of diabetic mice from wound margin. NFAT5 antibody: red, cell nucleus: Blue; E: The expressions of NFAT5 protein of mice from wound margin. ^aP < 0.05 Shikonin group vs blank group.