Tiliroside protects against diabetic nephropathy in streptozotocin-induced diabetes rats by attenuating oxidative stress and inflammation

Figure 11  Effect of Tiliroside on renal histopathology of experimental rats. Control rats exhibited a healthy tissue appearance with normal histoarchitectures (Group I). The streptozotocin (STZ)-provoked diabetic nephropathy (DN) animals showed shrinkage and necrosis of glomeruli (black arrows), renal tubular epithelial cell damage (blue arrows), edema (green arrows), and neutrophil infiltration (yellow arrows) (Group II). Tiliroside (Til) at three different doses i.e., 25, 50 mg/kg, and positive control Glibenclamide (GB) 600 μg/kg treated Diabetic nephropathy (DN) animals treated with Tiliroside (Til) at different doses, i.e., 25 and 50 mg/kg, and the positive control Glibenclamide (GB) 600 μg/kg demonstrated reduced histological changes such as reduced edema, glomerular and tubular damage, and neutrophil infiltration in renal tissues (Groups III and V, respectively). GB: Glibenclamide; TIL: Tiliroside; STZ: Streptozotocin.