Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications

Figure 2 Gene database-based target analysis of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes mellitus. A: Combination between “diabetes” and “cGAS-STING” predicted by String database (version 11.5); B: The 20 targets with the highest degree value; C: The protein interaction diagram of the interaction between “Akt” and “cGAS-STING”. mTOR: Mammalian target of rapamycin; cGAS: Cyclic guanosine monophosphate-adenosine monophosphate synthase; STING: Stimulator of interferon gene; TSC: Tuberous sclerosis complex; Akt: Activated protein kinase B; TBK: TANK binding kinase; IRF: Interferon regulatory factor 3; IFN: Interferon; IL: Interleukin; NF-κB: Nuclear factor-κB; PARP: Polyadenosine diphosphate-ribose polymer.