Association between sensitivity to thyroid hormones and non-high-density lipoprotein cholesterol levels in patients with type 2 diabetes mellitus

doi:10.4239/wjd.v15.i10.2081

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Oct 15, 2024; 15(10): 2081-2092
Published online Oct 15, 2024. doi: 10.4239/wjd.v15.i10.2081

Table 3 Relationships between lipid profiles and thyroid-associated variables

Variables		TG		TC		LDL-C		HDL-C		RC
Variables		r	P value	r	P value	r	P value	r	P value	r	P value
FT3 (pg/mL)	Model 1	-0.092^a	0.004	-0.116^a	< 0.001	-0.086^a	0.007	-0.093^a	0.004	-0.037	0.246
	Model 2	-0.114^a	< 0.001	-0.149^a	< 0.001	-0.106^a	0.001	-0.083^a	0.009	-0.081^b	0.011
	Model 3	-0.099^a	0.002	-0.137^a	< 0.001	-0.094^a	0.003	-0.097^a	0.003	-0.068^b	0.035
FT4 (ng/dL)	Model 1	-0.007	0.838	0.001	0.971	0.008	0.8	0.03	0.352	-0.032	0.312
	Model 2	-0.01	0.764	-0.003	0.928	0.006	0.84	0.03	0.349	-0.039	0.224
	Model 3	-0.02	0.535	-0.012	0.717	-0.002	0.948	0.037	0.249	-0.048	0.139
TSH (uIU/mL)	Model 1	0.074^b	0.021	0.045	0.157	0.04	0.206	-0.080^b	0.013	0.083^a	0.01
	Model 2	0.077^b	0.016	0.05	0.12	0.043	0.177	-0.082^b	0.01	0.09^a	0.005
	Model 3	0.082^b	0.01	0.063	0.05	0.056	0.084	-0.08^b	0.012	0.095^a	0.003
FT3/FT4	Model 1	-0.082^b	0.01	-0.093^a	0.003	-0.065^b	0.041	-0.141^a	< 0.001	0.008	0.802
	Model 2	-0.095^a	0.003	-0.114^a	< 0.001	-0.078^b	0.015	-0.134^a	< 0.001	-0.021	0.519
	Model 3	-0.061	0.06	-0.082^b	0.011	-0.045	0.167	-0.163^a	< 0.001	0.01	0.749
TT4RI	Model 1	0.079^b	0.013	0.052	0.102	0.046	0.147	-0.066^b	0.039	0.078^b	0.014
	Model 2	0.081^b	0.011	0.055	0.087	0.048	0.133	-0.068^b	0.034	0.082^b	0.01
	Model 3	0.081^b	0.012	0.065^b	0.043	0.057	0.075	-0.061	0.057	0.083^b	0.01
TSHI	Model 1	0.099^a	0.002	0.061	0.056	0.048	0.135	-0.066^b	0.039	0.095^a	0.003
	Model 2	0.1^a	0.002	0.063^b	0.049	0.049	0.126	-0.067^b	0.036	0.098^a	0.002
	Model 3	0.103^a	0.001	0.079^b	0.014	0.064^b	0.047	-0.059	0.065	0.102^a	0.002
TFQI	Model1	0.087^a	0.006	0.074^b	0.02	0.059	0.066	-0.003	0.922	0.061	0.054
	Model2	0.085^a	0.008	0.071^b	0.026	0.056	0.078	< 0.001	0.989	0.057	0.076
	Model3	0.068^b	0.035	0.068^b	0.035	0.052	0.106	0.02	0.529	0.043	0.181

^aP < 0.01

^bP < 0.05.

Model 1 was an unadjusted analysis. Model 2 was adjusted for age and sex. Model 3 was adjusted for age, sex, body mass index, and glycosylated hemoglobin. FT3: Free triiodothyronine; FT4: Free thyrotropin; TSH: Thyroid-stimulating hormone; TSHI: Thyroid-stimulating hormone index; TT4RI: Thyrotrophic T4 resistance index; TFQI: Thyroid feedback quantile-based index.

Citation: Duan XY, Fu JL, Sun LN, Mu ZJ, Xiu SL. Association between sensitivity to thyroid hormones and non-high-density lipoprotein cholesterol levels in patients with type 2 diabetes mellitus. World J Diabetes 2024; 15(10): 2081-2092
URL: https://www.wjgnet.com/1948-9358/full/v15/i10/2081.htm
DOI: https://dx.doi.org/10.4239/wjd.v15.i10.2081