Relationship between hemoglobin glycation index and risk of hypoglycemia in type 2 diabetes with time-in-range in target

Table 3 Clinical markers of glycemia variables for hypoglycemia analyzed by univariate and multiple logistic regression analyses

	Univariate logistic regression			Multiple logistic regression
	χ2	P value	OR (95%CI)	Wald χ2	P value	OR (95%CI)
Sex (female/male)	0.82	0.37	0.73 (0.36-1.45)
Age	4.25	0.04a	0.42 (0.19-0.96)
BMI	0.09	0.77	1.11 (0.55-2.25)
Laboratory HbA1c	0.36	0.55	0.81 (0.41-1.62)
Hemotocrit	1.81	0.18	1.75 (0.78-3.95)
MBG	4.26	0.04a	0.45 (0.21-0.96)	9.05	< 0.01a	0.17 (0.05-0.54)
SDBG	9.74	< 0.01a	3.44 (1.58-7.47)	5.30	0.02a	5.37 (1.28-22.46)
LAGE	3.41	0.07	7.56 (0.88-64.67)
MAGE	6.95	0.01a	2.62 (1.28-5.35)
MODD	0.32	0.57	1.36 (0.46-4.01)
HGI	6.98	< 0.01a	2.65 (1.29-5.44)	4.65	0.03a	2.46 (1.09-5.58)
Use of insulin and/or sulfonylurea	0.30	0.58	1.22 (0.60-2.51)

^aP < 0.05.

OR: Odds ratio; CI: Confidence interval; BMI: Body mass index; HbA1c: Hemoglobin A1c; MBG: Mean blood glucose; SDBG: Standard deviation blood glucose; LAGE: LAGE: Largest amplitude of glycemic excursions; MAGE: Mean amplitude of glucose excursion; MODD: Mean of daily differences; HGI: Hemoglobin glycation index.