Relationship between hemoglobin glycation index and risk of hypoglycemia in type 2 diabetes with time-in-range in target

Table 2 Continuous glucose monitoring parameters

Characteristic	Total	HGI < 0.5	HGI ≥ 0.5	P value
Participants, n (%)	129	72 (56)	57 (44)
GMI (%), mean ± SD	6.09 ± 0.67	6.11 ± 0.70	6.06 ± 0.63	0.752
Average glucose (mmol/L), mean ± SD	7.11 ± 1.06	7.13 ± 1.10	7.08 ± 1.02	0.885
SDBG (mmol/L), mean ± SD	1.67 ± 0.64	1.59 ± 0.63	1.77 ± 0.64	0.961
CV (%), mean ± SD	22.89 ± 7.65	21.41 ± 6.78	24.76 ± 8.31	0.017a
MAGE (mmol/L), mean ± SD	4.08 ± 1.81	3.88 ± 1.72	4.35 ± 1.91	0.742
LAGE (mmol/L), mean ± SD	8.86 ± 3.03	8.26 ± 2.89	9.63 ± 3.06	0.005a
MODD (mmol/L), medians (IQR)	1.40 (0.70)	1.30 (0.50)	1.50 (0.60)	0.024a
TIR (% of time 39-10 mmol/L), medians (IQR)	90 (17)	93.50 (13)	86 (16)	0.002a
TBR (% of time < 3.9 mmol/L), medians (IQR)	1 (5)	0 (2)	2 (11)	< 0.001a
TAR (% of time > 10 mmol/L), medians (IQR)	6 (13)	4.50 (11)	8 (12)	0.068

^aP < 0.05, compared with the values from two groups.

HGI: Hemoglobin glycation index; GMI: Glucose management indicator; SDBG: Standard deviation blood glucose; CV: Coefficient of variation; MAGE: Mean amplitude of glucose excursion; LAGE: Largest amplitude of glycemic excursions; MODD: Mean of daily differences; TIR: Time in range; TBR: Time below range; TAR: Time above range.