Copyright
©The Author(s) 2024.
World J Diabetes. Jan 15, 2024; 15(1): 53-71
Published online Jan 15, 2024. doi: 10.4239/wjd.v15.i1.53
Published online Jan 15, 2024. doi: 10.4239/wjd.v15.i1.53
Amino acids | Pooled (n = 97) | Obese (n = 22) | Overweight (n = 42) | Normal weight (n = 33) | ||||||||||||
VAT | Body weight | BMI | HDL | VAT | Body weight | BMI | HDL | VAT | Body weight | BMI | HDL | VAT | Body weight | BMI | HDL | |
Valine | 0.375b | 0.236a | 0.212a | NS | 0.311 | 0.217 | 0.009 | NS | 0.140 | 0.286c | 0.223 | NS | 0.150 | 0.008 | 0.167 | NS |
Isoleucine | 0.443b | 0.287b | 0.255a | -0.309b | 0.109 | 0.106 | -0.095 | NS | 0.347c | 0.289c | 0.301d | -0.417b | 0.351 | 0.047 | 0.114 | NS |
Leucine | 0.396b | 0.315b | 0.249a | -.276b | 0.120 | 0.201 | -0.068 | NS | 0.312 | 0.320a | 0.340a | -0.345a | 0.133 | 0.159 | 0.173 | NS |
Tyrosine | 0.524b | 0.341b | 0.301b | NS | 0.447 | 0.136 | 0.002 | NS | 0.251 | 0.343a | 0.094 | NS | -0.036 | 0.154 | 0.347a | NS |
Phenylalanine | 0.508b | 0.264b | 0.262a | -0.307b | 0.177 | 0.176 | 0.027 | NS | 0.607b | 0.096 | 0.171 | -0.323a | 0.185 | 0.156 | 0.085 | NS |
Tryptophan | 0.373a | 0.362b | 0.236a | NS | 0.382 | 0.076 | -0.230 | NS | 0.107 | 0.339a | 0.114 | NS | -0.042 | 0.280 | -0.012 | NS |
Methionine | 0.379b | 0.251a | 0.228a | NS | 0.229 | 0.223 | 0.105 | NS | 0.377c | 0.327a | 0.357a | NS | -0.263 | 0.050 | 0.296c | NS |
Taurine | -0.367a | -0.001 | 0.047 | NS | -0.479c | -0.043 | -0.164 | NS | -0.451a | -0.153 | 0.142 | NS | -0.345 | 0.083 | -0.082 | NS |
Alanine | 0.429b | 0.194d | 0.268b | NS | 0.640a | 0.178 | 0.078 | NS | -0.027 | -0.041 | -0.095 | NS | 0.304 | -0.171 | 0.043 | NS |
Asparagine | 0.278d | 0.218a | 0.079 | -0.222a | 0.200 | 0.333 | 0.049 | -0.478a | 0.129 | 0.287c | 0.008 | NS | -0.192 | 0.206 | -0.052 | NS |
Glutamine | 0.253c | 0.157 | 0.052 | NS | 0.422 | 0.075 | 0.042 | NS | -0.021 | 0.282c | 0.043 | NS | 0.000 | 0.070 | -0.072 | NS |
Glutamate | 0.398b | 0.263b | 0.234a | NS | 0.147 | 0.172 | 0.133 | NS | 0.291 | 0.181 | 0.021 | NS | -0.024 | 0.113 | -0.053 | NS |
Lysine | 0.390b | 0.272b | 0.203a | NS | 0.372 | 0.124 | 0.053 | NS | 0.237 | 0.277c | 0.090 | NS | -0.246 | 0.059 | -0.054 | NS |
Hydroxyproline | 0.293a | 0.025 | -0.008 | NS | -0.428 | 0.080 | 0.015 | -0.436a | 0.276 | 0.172 | 0.056 | NS | 0.192 | -0.105 | -0.171 | NS |
Threonine | 0.388b | 0.237a | 0.190c | NS | 0.573a | 0.322 | 0.233 | NS | 0.108 | 0.190 | 0.177 | NS | 0.012 | 0.088 | 0.005 | NS |
Citrulline | 0.118 | 0.035 | -0.046 | NS | -0.146 | -0.114 | -0.043 | NS | 0.068 | 0.231 | 0.015 | NS | -0.120 | -0.052 | -0.233 | NS |
Proline | 0.314a | 0.099 | 0.104 | NS | 0.295 | -0.015 | -0.162 | NS | 0.059 | 0.205 | -0.061 | NS | 0.018 | -0.310c | 0.047 | NS |
Homocysteine | -0.132 | 0.007 | -0.011 | NS | 0.232 | 0.475a | 0.431 | NS | -0.201 | -0.109 | -0.061 | NS | 0.251 | -0.015 | -0.020 | NS |
Histidine | 0.278d | 0.331b | 0.250a | NS | 0.316 | 0.358 | 0.123 | NS | 0.085 | 0.275c | 0.231 | NS | -0.274 | 0.100 | 0.012 | NS |
Arginine | 0.167 | 0.042 | 0.042 | NS | 0.097 | -0.189 | -0.226 | NS | 0.122 | 0.078 | -0.100 | NS | -0.215 | -0.182 | -0.088 | NS |
β-Alanine | -0.134 | -0.073 | -0.108 | NS | 0.241 | -0.108 | 0.069 | NS | -0.360c | -0.175 | -0.329a | NS | 0.193 | 0.306c | -0.037 | NS |
Carnosine | 0.278d | 0.162 | 0.157 | NS | 0.113 | -0.121 | -0.143 | NS | 0.056 | 0.062 | 0.054 | NS | -0.649a | 0.200 | -0.156 | NS |
Serine | 0.149 | 0.151 | 0.039 | -0.240a | -0.157 | -0.031 | -0.154 | NS | 0.121 | 0.159 | -0.121 | NS | -0.220 | 0.465b | 0.111 | NS |
- Citation: Wang M, Ou Y, Yuan XL, Zhu XF, Niu B, Kang Z, Zhang B, Ahmed A, Xing GQ, Su H. Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors. World J Diabetes 2024; 15(1): 53-71
- URL: https://www.wjgnet.com/1948-9358/full/v15/i1/53.htm
- DOI: https://dx.doi.org/10.4239/wjd.v15.i1.53