Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors

doi:10.4239/wjd.v15.i1.53

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jan 15, 2024; 15(1): 53-71
Published online Jan 15, 2024. doi: 10.4239/wjd.v15.i1.53

Table 1 Characteristics of 97 new-onset type 2 diabetes patients of normal weight, overweight and obesity

	NW (33)	OW (42)	OB (22)	F value	P value
Sex: M/F [n (%)]	20/13 (33)	24/18 (42)	13/9 (22)	0.095	0.954
Age (yr, mean ± SD)	43.64 ± 6.95	42.21 ± 9.76	36.77 ± 10.32^a	4.054	0.020^a
T2DM onset (d)	46.1 ± 96.8	41.8 ± 90.3	8.5 ± 20.2	1.569	0.214
Medication (Y/N)	13/20	13/29	6/16	1.016	0.602
Metformin equiv dose (g, mean ± SD)	176 ± 221	214 ± 225	546 ± 34	1.384	0.256
Weight (kg)	60.53 ± 6.87	73.49 ± 9.71^b^,^c	85.64 ± 11.35^b^,^c	49.593	0.000^b
Height (cm)	165.3 ± 8.26	168.5 ± 9.05	164.4 ± 6.91	1.407	0.250
BMI index	22.23 ± 1.60	25.88 ± 1.07^b^,^c	31.23 ± 2.31^b^,^c	208.086	0.000^b
Waist circumference (cm)	84.85 ± 6.21	89.76 ± 6.07^b^,^c	99.61 ± 7.05^b^,^c	35.920	0.000^b
Waist: Height ratio	0.514 ± 0.042	0.535 ± 0.034^a	0.604 ± 0.041^b^,^c	37.279	0.000^b
Systolic blood pressure (mmHg)	122.1 ± 17.6	125.6 ± 13.2	130.7 ± 18.2	12.68	0.07
Diastolic blood pressure (mmHg)	81.9 ± 12.8	83.8 ± 8.7	82.5 ± 15.7	0.509	0.602

^aP < 0.05 compared with normal weight.

^bP < 0.01, compared with normal weight.

^cP < 0.01, compared with overweight.

Data are numbers (n) of individuals (%) unless otherwise indicated. NW: Normal weight (body mass index: 18.5-23.9); OB: Obesity (body mass index: ≥ 28.0); OW: overweight (body mass index: 24.0-27.9); BMI: Body mass index; M: Male; F: Female.

Citation: Wang M, Ou Y, Yuan XL, Zhu XF, Niu B, Kang Z, Zhang B, Ahmed A, Xing GQ, Su H. Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors. World J Diabetes 2024; 15(1): 53-71
URL: https://www.wjgnet.com/1948-9358/full/v15/i1/53.htm
DOI: https://dx.doi.org/10.4239/wjd.v15.i1.53