XB130 inhibits healing of diabetic skin ulcers through the PI3K/Akt signalling pathway

Figure 9 Knock-down of XB130 attenuated hyperglycemia-induced inhibitory effects on human umbilical vein endothelial cells via PI3K/Akt signalling pathway. A: Western blot analysis of AKT and p-AKT expression in human umbilical vein endothelial cells; B: quantification of Western blot results; C: Immunofluorescence staining of Bax, cleaved caspase-3, PCNA, Ki67, and Bcl2 in each group; D: Wound healing assay in each group, scale bars = 200 μm; E: Capillary-like tubule formation, scale bars = 200 μm. ^aP < 0.01, compared to the high glucose group; ^bP < 0.05, compared to the HG + XB130-KD group.