Genipin relieves diabetic retinopathy by down-regulation of advanced glycation end products via the mitochondrial metabolism related signaling pathway

Figure 7 SCG3 plays a vital role in diabetic retinopathy via glycosylation. A: Structure of SCG3; B: Molecular docking simulation with RAGE (green, left) and SCG3 (orange, right); C: PNGase F cleavaged Scg₃. NG: 5 mmol/l glucose containing ECM-treated human retinal microvascular endothelial cells (hRMECs) group; HG: 30 mmol/L glucose containing ECM-treated hRMECs group; GG: 0.4 μM genipin + 30 mmol/L glucose containing ECM-treated hRMECs.