Analysis of N6-methyladenosine-modified mRNAs in diabetic cataract

Figure 2 Microarray data analysis showing expression profile of methylated mRNAs. A: Visualization of differential N6-methyladenosine (m6A) quantity profiles of mRNAs between the diabetic cataract (DC) and normal control (NC) groups through heat map and hierarchical clustering, where red and green colors indicate up- and down-regulated mRNAs, respectively; B: Volcano plot showing significant dysregulation of 10820 (7153 upregulated and 3667 downregulated) mRNAs in DC cases compared to NCs; C: Visualization of differential m6A mRNA methylation level profiles between DC cases and NCs through heat map and hierarchical clustering, where red and green colors indicate up- and down-regulated mRNAs, respectively; D: Volcano plot showing significant dysregulation of 1345 (1125 upregulated and 220 downregulated) methylated mRNAs in DC cases versus NCs.