Network-pharmacology-based research on protective effects and underlying mechanism of Shuxin decoction against myocardial ischemia/reperfusion injury with diabetes

Figure 8 Intraperitoneal glucose tolerance test, intraperitoneal insulin tolerance test, and international sensitivity index of rats. A: Intraperitoneal glucose tolerance test (IPGTT) at baseline; B: Average area under the curve (AUC) of IPGTT at baseline; C: Intraperitoneal insulin tolerance test (IPITT) at baseline; D: Average AUC of IPITT at baseline; E: IPGTT at the end of the experiment; F: IPITT at the end of the experiment; G: Average AUC of IPGTT at the end of the experiment; H: Average AUC of IPITT at the end of the experiment; I: International sensitivity index (ISI) at the end of the experiment. ISI = 1(/Log FPG × Log FINS). ^cP < 0.001 vs group C (n = 8-10 rats per group). IPGTT: Intraperitoneal glucose tolerance test; IPITT: Intraperitoneal insulin tolerance test; C: Normal control group; DS: Diabetic rats with sham operation group; MI/RI: Myocardial ischemia/reperfusion injury; DMR: MI/RI in diabetes group; SXTL: MI/RI in diabetic rats receiving SXT 0.7 g/kg/d group; SXTM: MI/RI in diabetic rats receiving SXT 1.4 g/kg/d group; SXTH: MI/RI in diabetic rats receiving SXT 2.8 g/kg/d group; AUC: Area under the curve.