Tight junction disruption and the pathogenesis of the chronic complications of diabetes mellitus: A narrative review

doi:10.4239/wjd.v14.i7.1013

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jul 15, 2023; 14(7): 1013-1026
Published online Jul 15, 2023. doi: 10.4239/wjd.v14.i7.1013

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Figure 6 Podocyte structure. A: Normal structure of the podocyte with the morphology of the foot process and the slit diaphragm; B: In diabetic nephropathy the podocyte structure and slit diaphragm are injured with slit diaphragm disruption, podocyte detachment and cytoskeleton rearrangement. These changes lead to albuminuria and progressive kidney disease. ROS: Reactive oxygen species; ZO: Zonula occludens.

Citation: Robles-Osorio ML, Sabath E. Tight junction disruption and the pathogenesis of the chronic complications of diabetes mellitus: A narrative review. World J Diabetes 2023; 14(7): 1013-1026
URL: https://www.wjgnet.com/1948-9358/full/v14/i7/1013.htm
DOI: https://dx.doi.org/10.4239/wjd.v14.i7.1013