Copyright
©The Author(s) 2023.
World J Diabetes. Jul 15, 2023; 14(7): 977-994
Published online Jul 15, 2023. doi: 10.4239/wjd.v14.i7.977
Published online Jul 15, 2023. doi: 10.4239/wjd.v14.i7.977
Neoplasia | Ligands and signaling pathway | Molecule expressed | Cancer hallmarks | TS/AM/CL | Ref. |
Breast cancer | AGE/RAGE, ERK1/2; Akt, c-fos | IL-8/CXCR1/2 | Migration and invasion | CL; CAFs, TNBC (MDA-MB-231 cells) | Santolla et al[137] |
HMGA1 | Cell proliferation, metastasis, and EMT | CL; TNBC (MDA-MB-231 and Hs578) | Shah et al[138] | ||
HMGB1/RAGE | Motility, migration, invasion, and dysregulation of metabolism | TS; human breast cancer, AM; NOD/SCID mice, CL; human breast cancer cells (MCF-7, T-470, BT474, MDA-MB-231, ZR-75-30, BT549) and human fibroblast cells HFL1 | Chen et al[139] | ||
HMGB1/PI3K/Akt | PD-L1 | Cell proliferation, migration, invasion, and T-cell apoptosis | CL; human breast cancer cells (MDA-MB-231 P, MDA-MB-231 BM) | Amornsupak et al[140] | |
HMGB1, PI3K/Akt, mTOR | HIF-1α, VEGF | Migration and angiogenesis | TS; human breast cancer CL; human breast cancer cells MCF-7 | He et al[141] | |
HMGB1/RAGE | Downregulation of miR-205 | Cell growth, invasion, and EMT | TS; human breast cancer CL; TNBC (MDA-MB-231, MDA-MB-453, MDA-MB-468) and NTNBC (MCF-7, MCF-10F) | Wang et al[142] | |
HMGB1/RAGE, ERK 1/2, CREB | Bone metastasis and neurite outgrowth of nervous system cells | AM; 4T1 mice CL; mouse breast cancer 4T1, primary rat nervous system cells DRG, rat DRG/mouse neuroblastoma hybrid cells F11, immortalized rat DRG neuronal cells 50B11 | Okui et al[143] | ||
S100A14/RAGE, NF-kB | CCL2/CXCL5 | Migration, invasion, and lung metastasis | TS; human breast cancer and paired adjacent breast normal, metastatic lymph node, and non-metastatic lymph node AM; BALB/c, BALB/c, SCID beige, C57BL/6J, CMV-CreC57BL/6J, S200-/- and S100A14-/- PyMT mice CL; human breast cancer cells MCF7, MCF10A, T47D, SKBR3, BT549, MDA-MB-231, MCF10AT, MCFCA1h, MCFCA1α and mouse breast cancer cells 4T1 | Li et al[144] | |
S100A7/RAGE, PI3K/Akt, ERK1/2, STAT3 | IGF-1 | Angiogenesis | CL; human breast cancer cells MCF-7, T47D, and HUVECs cells | Muoio et al[145] | |
S100A7/RAGE, cPLA | PGE2, CD163+ | Immunosuppression, M2-macrophages, CD4+, CD8+, and T cells | AM; NOD SCID gamma mice CL; human breast cancer cells MDA-MB-231, MDA-MB-468 and mouse mammary cancer cells MVT-1 | Mishra et al[146] | |
S100A8/A9-RAGE, FAK, Akt, Hippo-YAK | FLNA, CTGF, Cyr61 | Cell proliferation and migration | CL; HEK293T and TNBC (MDA-MB-23 and BT-549) | Rigiracciolo et al[147] | |
LPS/S100A7/TLR4/RAGE | Migration and invasion | AM; orthotopic breast cancer C57BL/6 mice model CL; murine mammary cancer cells EO771, MTV-1, murine metastatic mammary cells EO.2, human breast carcinoma cells SUM 159, MDA-MB-231 and MDA-MB-468 | Wilkie et al[148] | ||
acHMGB1/RAGE, S100A4/RAGE, Gas6/AXL | CXCR4, CXCL12, CCL2, CD151 and α3β1-integrin | Cell proliferation, invasion, intravasation, and EMT | AM; murine orthotopic mammary cancer CL; human MSCs, geminin overexpressing breast tumors Gem197, Gem240, Gem256, Gem257 and Gem270 cells, CAFs, and M0- TAMs and M2-TAMs | Ryan et al[149] | |
Colorectal cancer | S100A16 | Cancer prognostic marker | TS; human colorectal cancer | Sun et al[150] | |
HMGB1/RAGE | PD-1 | Cancer prognostic marker | TS; human colorectal cancer CL; human colorectal cancer cells SW480, and SW620 | Huang et al[151] | |
S100B/RAGE, NF-kB | VEGF-A | Proliferation, migration, and angiogenesis | CL; human colon cancer cells HCT116 | Zheng et al[152] | |
IGF1R-Ras/RAGE-HMGB1, | Oncogenesis | TS; Human colorectal from diabetic patients | Niu et al[153] | ||
AGEs/RAGE, KLF5 | MDM upregulation and RB and p53 downregulation | Cancer initiation and development | AM; diabetic mouse model and CL; human colon cancer cells HCT116 | Wang et al[154] | |
TCTP, HMGB1/RAGE, NF-kB | Invasion and metastasis | TS; human colorectal AM; tumor xenografts BALB/c nude mice CL; human colon adenocarcinoma cells LoVo | Huang et al[155] | ||
S100A9/RAGE/TLR4 | Arg-1, iNOS, IL-10 and ROS | Immune suppression and MDSC chemotaxis | TS; human colorectal cancer and normal colon CL; Human colorectal cells LoVo, and MDSCs | Huang et al[156] | |
HMGB1/RAGE, Kras/Yap1 | Cell proliferation | CL; human colorectal cancer cells HCT116 and SW480 | Qian et al[157] | ||
S100B/RAGE, p38/pAkt/mTOR | VEGF-R2, iNOS, VEGF | Cell proliferation, migration, invasion, and angiogenesis | CL; human colon adenocarcinoma cells CaCo | Seguella et al[158] | |
HMGB1/RAGE, pERK1/2, pDRP1 | Cell viability, autophagy, and chemoresistance | TS; human colorectal AM; athymic nude BALBC/c mice CL; human colorectal cells SW480, SW620, and LoVo | Huang et al[159] | ||
Hepatocellular carcinoma | S100A9-TLR4/RAGE-ROS, | NET | Cell proliferation, invasion, and metastasis | TS; HBV+ and HBV-hepatocellular carcinoma AM; BALB/c mice and C57BL/6 mice CL; human liver cells QSG-7701, human hepatocellular carcinoma cells HepG2.2.15, mouse hepatocellular carcinoma cells H22 and HUVEC cells | Zhan et al[160] |
HMGB1/RAGE | Cell proliferation and tumor differentiation | TS; primary hepatocellular carcinoma | Ando et al[161] | ||
HMGB1/RAGE, ATG7 | Cell proliferation, fibrosis, and autophagy | TS; mouse hepatocellular carcinoma AM; Atg7, RAGE, HMGB1 transgenic C57BL/6Jmouse | Khambu et al[128] | ||
HMGB1/RAGE, JNK, OCT4/TGFb1 | miR-21, CD44 | Migration and invasion | TS; human hepatocellular carcinoma AM; BALB/c nu/nu mice CL; human hepatocellular carcinoma cells HepG2, HCCLM3, Huh7, SMMC7721 and MHCC97H | Li et al[162] | |
S100A4/RAGE, b-catenin | OCT4, SOX2, CD44 and Nanog (stem cell-associated genes) | Fibrosis and carcinogenesis | TS; human hepatocellular carcinoma AM; S100a4-EGFP, S100A4+/+GFP, S100A4-/- transgenic mice. CL; human hepatocellular carcinoma cells Huh7 and murine liver cancer cells Hep1-6 | Li et al[163] | |
HMGB1/RAGE, ERK1/2 | CXCL2, IL-8, TNF, IL-6, IL-10, IL-23-p19 | Macrophage activation and inflammation | AM; primary murine hepatocytes from male C57BI/6J mice, and primary murine splenocytes from male C57BI/CJ CC; murine hepatoma cells Hepa1-6 and Hep-56.1D, human hepatoma cells HepG2, RAW 264.7 macrophages and monocytic cells THP1 | Bachmann et al[164] | |
HMGB1/RAGE, NF-kB | circRNA 101368, miR-200a | Cell migration | TS; human hepatocellular carcinoma CL; human hepatocellular carcinoma cells HCCLM3, MHCC97L, SMMC7721, Hep3B, HepG2 cells, and normal hepatocyte cells THLE-3 | Li et al[165] | |
Pancreatic cancer | RAGE | NET | Neutrophil autophagy | TS; human pancreatic carcinoma AM; Wild type C57BL6 mice and RAGE-/- C57BL6 mice, orthotopic pancreatic cancer model, CL; murine pancreatic cancer cells Panc02, MDSCs cells | Boone et al[166] |
RAGE, PI3K/AKT/mTOR | Cell viability | CL; human pancreatic cancer cells MIA Paca-2, BxPC-3, AsPC-1, HPAC, PANC-1, MIA PacaGEMR | Lan et al[167] | ||
RAGE, ERK1/2/Akt | Alpha 2 and alpha 1 integrin downregulation | Cell proliferation, invasion, and migration | CL; human pancreatic cancer cells Panc-1 | Swami et al[129] | |
AGE/RAGE, TGFb1 | a-SMA, collagen 1, IL-6 | Fibrosis and EMT | TS; human pancreatic ductal adenocarcinoma AM; WT-C57BL/6 and RG-C57BL/6 mice CL; primary PSC, human pancreatic ductal adenocarcinoma cells BxPC-3 and AsPC-1 | Uchida et al[168] | |
HMGB1/RAGE, PI3K/Akt | Atg5, Beclin-1, LC3-II | Autophagia and apoptosis inhibition | CL; human pancreatic cancer cells MIA Paca-2 and MIA PacaGEMR | Chen et al[169] |
- Citation: Garza-Campos A, Prieto-Correa JR, Domínguez-Rosales JA, Hernández-Nazará ZH. Implications of receptor for advanced glycation end products for progression from obesity to diabetes and from diabetes to cancer. World J Diabetes 2023; 14(7): 977-994
- URL: https://www.wjgnet.com/1948-9358/full/v14/i7/977.htm
- DOI: https://dx.doi.org/10.4239/wjd.v14.i7.977