Glucose metabolism profile recorded by flash glucose monitoring system in patients with hypopituitarism during prednisone replacement

Table 1 General characteristics and laboratory results of patient groups and normal controls

Parameters	PG	Pred (> 5 mg/d)	Pred (≤ 5 mg/d)	NCs	Reference range
Age (year-old)	52.85 ± 3.49	51.5 ± 4.78	49.88 ± 5.33	50.75 ± 3.05	-
Male:famle	5:15	3:9	2:6	5:15	-
BMI (kg/m2)	19.46 ± 1.39	20.02 ± 1.44	18.61 ± 0.81	20.5 ± 1.58	18.5-23.9
Disease duration (day)	730 (88.75, 1095)	730 (50, 1642.5)	730 (638.75, 1095)	-	-
Blood pressure (mmHg)	(108.65 ± 1.15)/(74.85 ± 0.89)	(108.25 ± 1.62)/(75.08 ± 1.36)	(109.25 ± 1.65)/(74.5 ± 0.98)	(111.95 ± 1.17)/(73.5 ± 0.7)
Pred dose (mg/d)	6.19 ± 1.54	7.29 ± 0.48	4.53 ± 0.93	-	-
ACTH (pmol/L)	3.5 ± 0.33	3.58 ± 0.51	3.37 ± 0.33	4.40 ± 0.41	1.6-13.9
Cortisol at 8 am (nmol/L)	228.01 ± 4.42	230.24 ± 6.84	224.66 ± 4.44	372.90 ± 16.69	171-536
Cortisol at 4 pm (nmol/L)	153 ± 11.99	165.93 ± 17.48	133.6 ± 12.87	159.10 ± 14.62	64-327
Cortisol at 0 am (nmol/L)	111.55 ± 8.85	113.31 ± 12.01	108.91 ± 13.76	-	-
UFC (nmol/24h)	141.33 ± 11.34	131.80 ± 10.41	155.61 ± 23.86	-	100-279
FT3 (pmol/L)	4.25 ± 0.13	4.24 ± 0.15	4.27 ± 0.25	5.20 ± 0.14	3.1-6.8
FT4 (pmol/L)	14.11 ± 0.55	13.45 ± 0.50	15.09 ± 1.10	12.98 ± 0.92	10-23
TSH (μIU/ml)	1.076 ± 0.16	1.1 ± 0.19	1.04 ± 0.28	2.30 ± 0.19	0.27-4.2
Plasma sodium (mmol/L)	141.95 ± 0.86	140.3 ± 0.65	142.63 ± 1.07	140.6 ± 0.55	137-147

Pred: Prednisone; NCs: Normal controls; BMI: Body mass index; ACTH: Adrenocorticotropic-hormone; UFC: Urine free cortisol; FT3: Free triiodothyronine; FT4: Free thyroxine; TSH: Thyroid stimulation hormone. The laboratory tests were conducted in patient group during prednisone treatment.