Correlation between glycated hemoglobin A1c, urinary microalbumin, urinary creatinine, β2 microglobulin, retinol binding protein and diabetic retinopathy

Table 5 Receiver operator characteristic curve analysis of glycated hemoglobin A1c, microalbumin, microalbumin /urinary creatinine, urinary creatinine, β2 microglobulin, retinol binding protein for predicting proliferative diabetic retinopathy

Item	Cut-off	Standard error	AUC	95%CI	Sensitivity (%)	Specificity (%)
mALB	56.84 mg/L	0.040	0.641	0.530-0.688	68. 82	71.24
mALB/U-CR	2.45 mg/mmoL	0.046	0.726	0.728-0.876	70.38	73.85
U-CR	25.96 μmol/L	0.004	0.757	0.508-0.722	72.49	75.58
β2MG	3.18 mg/L	0.027	0.748	0.637-0.882	76.84	79.84
RBP	26.58 μg/L	0.036	0.807	0.637-0.882	82.48	79.38
HbA1c	9.05%	0.043	0.710	0.638-0.775	72.41	63.11
Combination	-	0.017	0.958	0.917-0.982	94.83	96.72

AUC: Area under the curve; U-mALB: Urinary microalbumin; U-CR: Urinary creatinine; β2MG: β2 microglobulin; RBP: Retinol binding protein; HbA1c: Glycated hemoglobin A1c; Combination: Glycated hemoglobin A1c + microalbumin + microalbumin/urinary creatinine + urinary creatinine + β2 microglobulin + retinol binding protein.