Network-pharmacology-based research on protective effects and underlying mechanism of Shuxin decoction against myocardial ischemia/reperfusion injury with diabetes

Table 2 Results of serum lipid metabolism indexes in rats

Group	TC (mmol/L)	TG (mmol/L)	FFA (mmol/L)	LDL-C (mmol/L)	HDL-C (mmol/L)
C	1.10 ± 0.20	0.60 ± 0.10	0.41 ± 0.02	0.74 ± 0.08	1.66 ± 0.11
DS	2.50 ± 0.20c	1.54 ± 0.07c	0.78 ± 0.02c	1.53 ± 0.06c	0.81 ± 0.07c
DMR	2.63 ± 0.15c	1.54 ± 0.08c	0.77 ± 0.03c	1.51 ± 0.03c	0.81 ± 0.06c
SXTL	2.17 ± 0.21c	1.46 ± 0.09c	0.69 ± 0.03c,d	1.47 ± 0.03c	0.97 ± 0.06c
SXTM	1.90 ± 0.20b,e	1.30 ± 0.08c,d	0.66 ± 0.04c,e	1.32 ± 0.04c,e	1.05 ± 0.08c
SXTH	1.85 ± 0.15b,e	1.30 ± 0.02c,d	0.61 ± 0.02c,f	1.34 ± 0.05c,d	1.08 ± 0.14c,d

^bP < 0.01.

^cP < 0.001 vs group C.

^dP < 0.05.

^eP < 0.01.

^fP < 0.001 vs group DMR (n = 3 rats per group).

Results are expressed as the mean ± SD. C: Normal control group; DS: Diabetic rats with sham operation group; MI/RI: Myocardial ischemia/reperfusion injury; DMR: MI/RI in diabetes group; SXTL: MI/RI in diabetic rats receiving SXT 0.7 g/kg/d group; SXTM: MI/RI in diabetic rats receiving SXT 1.4 g/kg/d group; SXTH: MI/RI in diabetic rats receiving SXT 2.8 g/kg/d group; TC: Total cholesterol; TG: Total triglycerides; FFA: free fatty acids; LDL-C: Low-density lipoprotein cholesterol; HDL-C: High density lipoprotein cholesterol.