Network-pharmacology-based research on protective effects and underlying mechanism of Shuxin decoction against myocardial ischemia/reperfusion injury with diabetes

Table 1 Forty-one Shuxin decoction key therapeutic targets for myocardial ischemia/reperfusion injury in diabetes

ID	Target	Protein name	Degree	Betweenness	Closeness
1	IL-6	Interleukin-6	54	0.047667394	0.95
2	IL-1β	Interleukin-1beta	53	0.029250817	0.93442623
3	TNF	Tumor Necrosis Factor	53	0.029250817	0.93442623
4	VEGFA	Vascular Endothelial Growth Factor A	51	0.022294667	0.904761905
5	MMP9	Matrix Metallopeptidase 9	49	0.016493589	0.876923077
6	CXCL8	C-X-C Motif Chemokine Ligand 8	48	0.017645476	0.863636364
7	STAT3	Signal Transducer and Activator of Transcription 3	48	0.014004747	0.863636364
8	PTGS2	Prostaglandin-Endoperoxide Synthase 2	48	0.012914899	0.863636364
9	CASP3	Caspase 3	48	0.017524977	0.863636364
10	TP53	Tumor Protein P53	47	0.013024421	0.850746269
11	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	47	0.010160499	0.850746269
12	PPARG	Peroxisome Proliferator Activated Receptor Gamma	45	0.017202087	0.826086957
13	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	45	0.01117217	0.826086957
14	IL-10	Interleukin-10	45	0.010195923	0.826086957
15	ICAM1	Intercellular Adhesion Molecule 1	43	0.009172336	0.802816901
16	NOS3	Nitric Oxide Synthase 3	42	0.021291387	0.791666667
17	HMOX1	Heme Oxygenase 1	41	0.005343813	0.780821918
18	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	40	0.017888649	0.77027027
19	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	39	0.007362402	0.76
20	IFNγ	Interferon Gamma	38	0.003891145	0.75
21	EDN1	Endothelin 1	37	0.007764542	0.74025974
22	CASP8	Caspase 8	37	0.007408849	0.74025974
23	MAPK8	Mitogen-Activated Protein Kinase 8	37	0.009018794	0.74025974
24	VCAM1	Vascular Cell Adhesion Molecule 1	37	0.00621228	0.74025974
25	CCND1	Cyclin D1	36	0.005854834	0.730769231
26	SERPINE1	Serpin Family E Member 1	36	0.004739025	0.730769231
27	MAPK14	Mitogen-Activated Protein Kinase 14	35	0.0033994	0.721518987
28	STAT1	Signal Transducer and Activator of Transcription 1	35	0.002891632	0.721518987
29	ESR1	Estrogen Receptor 1	34	0.005648692	0.7125
30	MPO	Myeloperoxidase	33	0.007272867	0.703703704
31	NOS2	Nitric Oxide Synthase 2	33	0.002943975	0.703703704
32	CASP1	Caspase 1	32	0.003275919	0.695121951
33	SPP1	Secreted Phosphoprotein 1	32	0.002473838	0.695121951
34	IL1A	Interleukin 1 Alpha	31	0.001235526	0.686746988
35	SELE	Selectin E	31	0.003528291	0.686746988
36	NFE2L2	Nuclear Factor, Erythroid 2 Like 2	30	0.003874065	0.678571429
37	CASP9	Caspase 9	30	0.003883128	0.678571429
38	PPARA	Peroxisome Proliferator Activated Receptor Alpha	30	0.001620936	0.678571429
39	KDR	Kinase Insert Domain Receptor	28	0.001361612	0.662790698
40	CXCL10	C-X-C Motif Chemokine ligand 8	27	0.000671	0.655172414
41	CD40LG	CD40 ligand	27	0.003513977	0.655172414