Type 2 diabetes and thyroid cancer: Synergized risk with rising air pollution

Table 4 Summary of the impact of ozone on human health

Type of interaction	Ref. (PMID)
Ozone results in increased gene expression	18332784
Ozone affects heart contraction	18091001
Ozone affects the regulation of inflammatory response	18560490
Ozone results in increased interleukin-6 production	20056584
[Vehicle Emissions co-treated with Ozone] affects neutrophil, lymphocyte, and monocyte homeostasis	27058360
[Air Pollutants results in increased abundance of Ozone] which results in increased DNA methylation	27219456
DNMT1 gene polymorphism affects the reaction [[Air Pollutants results in increased abundance of Ozone] which affects the regulation of blood pressure]	27219456
Ozone results in increased cholesterol metabolic process	27703007
[Cholesterol co-treated with Ozone] results in increased protein lipidation	27703007
Ozone results in increased mRNA and rRNA transcription	28652203
[Dust co-treated with Ozone] results in increased negative regulation of lymphoid progenitor cell differentiation	29767793
[Dust co-treated with Ozone] results in increased positive regulation of reactive oxygen species biosynthetic process	29767793
Ozone results in increased positive regulation of glycolytic process and cellular response to oxidative stress	29471466
Ozone results in increased positive regulation of proteolysis and amino acid metabolic process	29471466
Ozone affects the regulation of the membrane lipid metabolic process	29471466
Ozone results in increased tissue regeneration	29471466
[Air Pollutants results in increased abundance of Ozone] which affects the regulation of heart rate	28129768
Ozone results in increased positive regulation of ERK1, ERK2, and p38MAPK cascade	29925859
Ozone results in increased iron ion transport, homeostasis	24862973
Ozone results in increased viral entry into the host cell and the viral life cycle	22496898
Ozone results in increased chloride transmembrane transport	27886375
Ozone affects cytokine production involved in the immune response	32000783
[Air Pollutants results in increased abundance of Ozone] which results in increased positive regulation of heart rate	31349208
[Ozone results in increased oxidation of dimethylselenide] which results in increased ncRNA transcription	33656867
Ozone affects the aspartate/glutamate/ornithine/taurine metabolic process	33993003
[Oxygen co-treated with Ozone] results in the decreased cellular metabolic process	32992648
[Oxygen co-treated with Ozone] results in increased necrotic cell death	32992648
[Air Pollutants results in increased abundance of Ozone] which affects T cell homeostasis	33603036

Data source: The comparative toxicogenomic database (http://ctdbase.org/)[12].