Type 2 diabetes and thyroid cancer: Synergized risk with rising air pollution

Table 3 Summary of the impact of nitrogen dioxide on human health

Type of interaction	Ref. (PMID)
Regulation of inflammatory response	18560490
Regulation of gene expression	22306530
Glucose metabolic process	26166095
[Air Pollutants result in an increased abundance of NO2] which affects the regulation of blood pressure	27219456
[Nitrogen Dioxide results in decreased mitochondrial DNA metabolic process] which affects the expression of ND1 mRNA	26317635
[Air Pollutants results in increased abundance of Nitrogen Dioxide] which affects DNA methylation on cytosine within a CG sequence	27448387
[Air Pollutants results in increased abundance of NO2] which results in decreased hemoglobin biosynthesis	28153527
[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which results in increased positive regulation of interleukin-6/10/13/ tumor necrosis factor (TNF) production	28669936
[Air Pollutants results in increased abundance of NO2] which results in increased response to oxidative stress	27015811
Nitrogen Dioxide affects musculoskeletal movement	29364820
[Air Pollutants results in increased abundance of NO2] which results in decreased cognition	28921105
[Air Pollutants results in increased abundance of NO2] which results in decreased motor behavior	28921105
Decreased leukocyte homeostasis	30826618
cytokine-mediated signaling pathway	29114965
[Air Pollutants results in increased abundance of NO2] which results in increased negative regulation of telomere maintenance	31393792
Cytokine production is involved in the immune response	32000783
[[Air Pollutants results in increased abundance of NO2] which affects glucose homeostasis] which affects the abundance of Blood Glucose	32552747
[[Air Pollutants results in increased abundance of NO2] which affects the regulation of cholesterol metabolic process] which affects the abundance of Cholesterol	31622905
[Air Pollutants results in increased abundance of NO2] which affects T cell homeostasis	33603036
[Air Pollutants results in increased abundance of NO2] which affects B cell homeostasis	33603036
[[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of NO2] which results in increased negative regulation of cholesterol metabolic process] which results in decreased abundance of cholesterol, HDL, and membrane lipid catabolic process	34417545

Data source: The comparative toxicogenomic database (http://ctdbase.org/)[12].