Type 2 diabetes and thyroid cancer: Synergized risk with rising air pollution

Table 2 Summary of the impact of carbon monoxide on human health

Type of interaction	Ref. (PMID)
Carbon Monoxide inhibits the reaction [Rotenone results in increased apoptotic process]	23593279
Carbon Monoxide results in the decreased xenobiotic catabolic process	7908050
Carbon Monoxide inhibits the reaction [NADP results in increased oxidative demethylation]	8498088
[IL6 gene SNP results in increased susceptibility to Carbon Monoxide] which results in increased positive regulation of interleukin-6 production	19750100
[Air Pollutants results in increased abundance of Carbon Monoxide] which results in decreased response to bronchodilator	26187234
Carbon Monoxide results in an increased inflammatory response	23717615
[Air Pollutants result in an increased abundance of Carbon Monoxide] which affects the regulation of blood pressure	28732501
[Air Pollutants results in increased abundance of Carbon Monoxide] which affects the regulation of heart rate	28129768
Carbon Monoxide inhibits the reaction [HMOX1 protein affects the reaction [Ammonium Chloride inhibits the reaction [[TNF protein co-treated with Cycloheximide] results in decreased cell growth]]]	27867098
Carbon Monoxide inhibits the reaction [[TNF protein co-treated with Cycloheximide] results in decreased cell growth]	27867098
Carbon Monoxide results in decreased leukocyte homeostasis	30826618
Carbon Monoxide results in the decreased respiratory system process	31861594|32000783
Carbon Monoxide affects cytokine production involved in the immune response	32000783
[Air Pollutants results in increased abundance of Carbon Monoxide] which affects T cell homeostasis	33603036
[Air Pollutants result in an increased abundance of Carbon Monoxide] which affects the regulation of blood pressure	33603036
[[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Monoxide] which results in increased membrane lipid catabolic process] which results in increased abundance of 8-epi-prostaglandin F2alpha	34417545

Data source: The comparative toxicogenomic database (http://ctdbase.org/)[12].