What’s old is new again: Insights into diabetic foot microbiome

Figure 1 Risk factors for the development of diabetic foot infections. Angiopathy and neuropathy are the main predisposing factors of diabetic foot infections (DFIs), together with muscular atrophy and extrinsic triggers, such as trauma, in the presence of abnormal immunity and ischemia as aggravating factors. These factors collectively result in the loss of skin integrity favoring the development of DFIs. The Meggitt-Wagner classification is commonly used to grade the DFIs (from 1 to 5) on three characteristics: the depth of ulcer; the degree of infection; and the necrosis.