Genetics of diabetes

Table 2 Studies on polygenic risk score for type 1 diabetes mellitus and type 2 diabetes mellitus

Diabetes type	SNPs	AUC for PRS	Ethnicity	Ref.
T1DM	41	0.87	Caucasian	[140]
T1DM	30	0.88	Caucasian	[141]
T1DM + T2DM	99	0.89	Caucasian
T1DM	32	0.86	Caucasian	[142]
T1DM	32	0.90	Caucasian Hispanic
T1DM	32	0.75	African-American
T1DM	32	0.92	Asian-American
T1DM	67	0.93	Caucasian	[143]
T2DM	3	0.58	Caucasian	[144]
T2DM	18	0.80	Caucasian	[136]
T2DM	16	0.75	Caucasian	[134]
T2DM	18	0.91	Caucasian	[135]
T2DM	22	0.74	Caucasian	[145]
T2DM	62	0.91	Caucasian United States population	[146]
T2DM	1000	0.79	Caucasian	[147]
T2DM	4	0.67	African	[148]
T2DM	7 million	0.73	Caucasian	[149]

SNP: Single nucleotide polymorphisms; AUC: Area under the curve; PRS: Polygenic risk score; T1DM: Type 1 diabetes mellitus; T2DM: Type 2 diabetes mellitus.