Association of bone turnover biomarkers with severe intracranial and extracranial artery stenosis in type 2 diabetes mellitus patients

Table 3 Association of bone turnover biomarker levels with artery stenosis

Variable	Model	OR (95%CI)	P value
OC	Model 1	1.123 (1.049-1.203)	0.001
	Model 2	1.117 (1.041-1.199)	0.002
	Model 3	1.117 (1.039-1.201)	0.003
	Model 4	1.109 (1.029-1.196)	0.007
CTX	Model 1	9.750 (1.759-54.059)	0.009
	Model 2	8.674 (1.529-49.211)	0.015
	Model 3	10.833 (1.725-68.037)	0.011
	Model 4	8.526 (1.189-61.119)	0.033
PINP	Model 1	1.024 (1.006-1.042)	0.010
	Model 2	1.022 (1.003-1.041)	0.025
	Model 3	1.022 (1.003-1.042)	0.021
	Model 4	1.020 (1.001-1.040)	0.044

Model 1: Unadjusted, crude model; Model 2: Adjusted for age and gender; Model 3: Further adjusted for hypertension, hyperlipidemia, coronary artery disease, duration of type 2 diabetes mellitus, current smoker, current drinker; Model 4: Further adjusted for body mass index, serum creatinine, blood urea nitrogen, uric acid, and hemoglobin. OC: Osteocalcin; CTX: C-terminal cross-linked telopeptide of type I collagen; PINP: Procollagen type I N-peptide.