Tongxinluo promotes endothelium-dependent arteriogenesis to attenuate diabetic peripheral arterial disease

Figure 6 Tongxinluo strengthened the crosstalk between endothelial cells and smooth muscle cells to induce smooth muscle cell proliferation and migration. A-D: Western blot analysis of the expression of Jagged-1, Notch-1 and ephrin-B2, which are related to the signaling pathway that mediates endothelial-smooth muscle cells interactions; E: Quantitative analysis of PCNA mRNA expression was determined via RT-PCR; F-H: Western blot analysis of the expression of the cell proliferation-associated proteins matrix metalloproteinase 9 (MMP9) and MMP2 in the ischemic adductor. The values are shown as the means ± SDs. ^aP < 0.05 compared with the normal group, ^bP <0.05 compared with the model group, ^cP < 0.05 compared with the Tongxinluo group, n = 3. TXL: Tongxinluo; MMP9: Matrix metalloproteinase 9.