miR-124 is upregulated in diabetic mice and inhibits proliferation and promotes apoptosis of high-glucose-induced β-cells by targeting EZH2

Figure 4 miR-124 protected pancreatic B cell function by targeting EZH2. A and B: The relative expression levels of EZH2 mRNA and protein were downregulated by si-EZH2 in high glucose (HG)-induced Min6 cells detected by real-time quantitative polymerase chain reaction and Western blot; C: miR-124 inhibitor promoted the proliferation ability of HG-induced Min6 cells by targeting EZH2; D: miR-124 inhibitor promoted the transition from the G0/G1 phase to the S phase at the cell cycle by targeting EZH2; E: miR-124 inhibitor suppressed the apoptosis of HG-induced Min6 cells by targeting EZH2; F: miR-124 inhibitor increased the secretion of insulin in HG-induced Min6 cells by targeting EZH2. ^aP < 0.05, vs miR-124 inhibitor + si-NC group. NC: Normal control; BC: Blank control; HG: High glucose.