Effectiveness and safety of traditional Chinese medicine decoction for diabetic gastroparesis: A network meta-analysis

Table 2 Odds ratio/weight mean difference (95% credible interval) results of the network meta-analysis

Clinical effects	BXXD	BXXD_WM	CQWD	CSLJD	CSLJD_WM	JPXZD	SMD
BXXD	1
BXXD_WM	0.72 (0.36, 1.4)	1
CQWD	0.93 (0.48, 1.76)	1.29 (0.61, 2.74)	1
CSLJD	0.83 (0.36, 1.83)	1.16 (0.47, 2.77)	0.9 (0.37, 2.11)	1
CSLJD_WM	2.21 (0.44, 10.19)	3.07 (0.58, 14.99)	2.38 (0.46, 11.51)	2.65 (0.48, 13.86)	1
JPXZD	0.87 (0.38, 1.89)	1.21 (0.5, 2.91)	0.94 (0.39, 2.18)	1.05 (0.39, 2.81)	0.39 (0.08, 2.17)	1
SMD	1.14 (0.57, 2.24)	1.58 (0.73, 3.46)	1.23 (0.57, 2.61)	1.37 (0.56, 3.42)	0.52 (0.11, 2.73)	1.3 (0.54, 3.23)	1
SMD_WM	0.72 (0.14, 2.73)	1 (0.19, 3.99)	0.77 (0.15, 3.07)	0.86 (0.15, 3.77)	0.32 (0.04, 2.5)	0.82 (0.15, 3.57)	0.63 (0.12, 2.56)
WM	3.93 (2.66, 5.91)	5.44 (3.25, 9.61)	4.23 (2.57, 7.18)	4.71 (2.4, 9.83)	1.79 (0.4, 8.59)	4.49 (2.33, 9.28)	3.44 (2, 6.13)
XSLJZD	1.57 (0.84, 2.9)	2.17 (1.07, 4.5)	1.68 (0.84, 3.41)	1.88 (0.82, 4.46)	0.71 (0.15, 3.64)	1.79 (0.79, 4.22)	1.37 (0.66, 2.87)
XSLJZD_WM	0.93 (0.44, 1.92)	1.3 (0.57, 2.94)	1.01 (0.45, 2.21)	1.12 (0.44, 2.88)	0.42 (0.08, 2.27)	1.07 (0.43, 2.72)	0.82 (0.36, 1.86)
ZSXPD	0.87 (0.4, 1.83)	1.2 (0.52, 2.79)	0.94 (0.4, 2.11)	1.04 (0.4, 2.71)	0.39 (0.08, 2.13)	1 (0.39, 2.58)	0.76 (0.32, 1.78)
Nausea and vomiting scores	BXXD	BXXD_WM	CQWD	JPXZD	SMD	SMD_WM	WM
BXXD	0
BXXD_WM	0.65 (0.17, 2.5)	0
CQWD	0.79 (0.23, 2.77)	1.22 (0.42, 3.65)	0
JPXZD	0.61 (0.14, 2.69)	0.95 (0.25, 3.63)	0.78 (0.23, 2.62)	0
SMD	0.41 (0.07, 2.43)	0.63 (0.12, 3.44)	0.52 (0.1, 2.52)	0.66 (0.11, 3.94)	0
SMD_WM	2.93 (0.46, 18.72)	4.52 (0.78, 26.05)	3.71 (0.69, 19.4)	4.79 (0.75, 30.37)	7.18 (0.87, 60.2)	0
WM	0.4 (0.14, 1.14)	0.61 (0.26, 1.45)	0.5 (0.26, 0.97)	0.65 (0.23, 1.82)	0.97 (0.23, 4.19)	0.14 (0.03, 0.63)	0
XSLJZD	0.47 (0.08, 2.84)	0.72 (0.13, 3.97)	0.59 (0.12, 2.92)	0.77 (0.13, 4.62)	1.15 (0.15, 9.16)	0.16 (0.02, 1.35)	1.18 (0.28, 5.13)
Anorexia scores	BXXD_WM	CQWD	SMD	SMD_WM	WM	XSLJZD	XSLJZD_WM
BXXD_WM	0
CQWD	0.37 (0.07, 1.66)	0
SMD	0.19 (0.02, 1.62)	0.52 (0.06, 4.56)	0
SMD_WM	2.08 (0.22, 18.36)	5.67 (0.62, 50.9)	10.86 (0.76, 158.85)	0
WM	0.19 (0.06, 0.55)	0.52 (0.17, 1.53)	0.99 (0.15, 6.46)	0.09 (0.01, 0.62)	0
XSLJZD	0.25 (0.03, 2.07)	0.67 (0.08, 5.77)	1.29 (0.09, 18.09)	0.12 (0.01, 1.69)	1.3 (0.2, 8.38)	0
XSLJZD_WM	1.27 (0.13, 11.66)	3.47 (0.36, 32.67)	6.63 (0.43, 99.8)	0.61 (0.04, 9.45)	6.69 (0.93, 48.32)	5.14 (0.34, 77.76)	0
Early satiety scores	BXXD	BXXD_WM	CQWD	JPXZD	SMD	SMD_WM	WM
BXXD	0
BXXD_WM	2.95 (0.77, 13.01)	0
CQWD	1.88 (0.43, 8.37)	0.64 (0.19, 1.89)	0
JPXZD	0.74 (0.18, 2.99)	0.25 (0.09, 0.65)	0.39 (0.13, 1.22)	0
SMD	0.5 (0.09, 2.79)	0.17 (0.04, 0.68)	0.27 (0.06, 1.23)	0.68 (0.17, 2.78)	0
SMD_WM	2.67 (0.46, 15.44)	0.9 (0.19, 3.71)	1.42 (0.3, 6.7)	3.61 (0.84, 15.32)	5.32 (0.9, 31.54)	0
WM	0.49 (0.15, 1.62)	0.16 (0.07, 0.32)	0.26 (0.11, 0.63)	0.66 (0.33, 1.33)	0.97 (0.28, 3.36)	0.18 (0.05, 0.65)	0
Bloating scores	BXXD	BXXD_WM	CQWD	JPXZD	SMD	SMD_WM	WM
BXXD	0
BXXD_WM	1.1 (0.58, 2.21)	0
CQWD	0.93 (0.49, 1.79)	0.85 (0.49, 1.42)	0
JPXZD	0.65 (0.33, 1.29)	0.59 (0.32, 1.03)	0.7 (0.4, 1.2)	0
SMD	0.45 (0.17, 1.16)	0.41 (0.17, 0.96)	0.48 (0.2, 1.12)	0.69 (0.29, 1.68)	0
SMD_WM	2.66 (1, 7.13)	2.42 (0.95, 5.89)	2.86 (1.16, 6.92)	4.11 (1.63, 10.31)	5.92 (1.91, 18.3)	0
WM	0.44 (0.26, 0.76)	0.4 (0.26, 0.58)	0.47 (0.33, 0.66)	0.68 (0.44, 1.04)	0.98 (0.45, 2.13)	0.17 (0.07, 0.38)	0
XSLJZD	0.56 (0.26, 1.18)	0.5 (0.25, 0.95)	0.6 (0.31, 1.11)	0.86 (0.43, 1.69)	1.23 (0.48, 3.16)	0.21 (0.08, 0.55)	1.26 (0.74, 2.13)
MOT	BXXD	BXXD_WM	CQWD	CSLJD	CSLJD_WM	JPXZD	SMD
BXXD	0
BXXD_WM	73145227955313819658 (16.53, 2.030196546848e + 38)	0
CQWD	35423305.81 (0, 5.93544195488604e + 21)	0 (0, 1661.84)	0
CSLJD	1.49786530431541e + 62 (3.50996919314233e + 43, 5.47316977723933e + 80)	2.12100175311827e + 42 (7.96830853291658e + 22, 6.07610382119557e + 61)	4.41194389881838e + 54 (1.64238728480315e + 39, 1.56982913306051e + 70)	0
CSLJD_WM	2.02292315583141e + 56 (2.13482601427363e + 38, 3.74341135713198e + 73)	3.39246479689985e + 36 (332081441777967616, 3.74853474640655e + 54)	6.5996363207526e + 48 (1.22057356959688e + 34, 6.1480125702437e + 62)	0 (0, 2732647433755.58)	0
JPXZD	1.46545014434071e + 35 (1.63502079852166e + 21, 1.17286388222191e + 49)	2074599066114823 (1.29, 3.17467766771584e + 30)	3.84186585617681e + 27 (1237249559868129024, 2.96562509673173e + 37)	0 (0, 0)	0 (0, 0)	0
SMD	4.20171429734073e + 26 (25898.14, 8.26692473710835e + 48)	6849152.53 (0, 9.10517874469878e + 29)	11853726740880627712 (0.26, 1.11780444531916e + 39)	0 (0, 0)	0 (0, 0)	0 (0, 116505229632.1)	0
SMD_WM	2.28758076383624e + 34 (3326609644123.49, 7.88309912633195e + 55)	281406176126933 (0, 7.9670020400884e + 36)	5.89642990959044e + 26 (39869414.39, 9.32616031295542e + 45)	0 (0, 0)	0 (0, 1.24)	0.14 (0, 954822479322721408)	39739999.76 (0, 2.14570758341921e + 33)
WM	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
XSLJZD_WM	14666.56 (0, 16247355947961442304)	0 (0, 8.34)	0 (0, 158351284.3)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.01)
ZSXPD	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
SS	BXXD	BXXD_WM	CQWD	SMD_WM	WM	XSLJZD_WM	ZSXPD
BXXD	0
BXXD_WM	0.01 (0, 36713863287.61)	0
CQWD	240.28 (0, 462592820033121344)	18640.19 (0, 4.5779943358534e + 19)	0
SMD_WM	0.11 (0, 224930986970319)	8.59 (0, 17667828742718418)	0 (0, 248861236102597)	0
WM	53749.9 (0, 32864187823875.5)	4200830.54 (0.01, 3136485942463265)	224.17 (0, 839932932110503)	493063.5 (0, 1651805622636769024)	0
XSLJZD_WM	50.96 (0, 102248837325752448)	3884.92 (0, 10556005822499647488)	0.2 (0, 117147511992865184)	472.76 (0, 2.04812782178715e + 20)	0 (0, 3009685068.16)	0
ZSXPD	0 (0, 0.04)	0 (0, 3.92)	0 (0, 0.14)	0 (0, 224.03)	0 (0, 0)	0 (0, 0.5)	0
GAS	BXXD	BXXD_WM	CQWD	JPXZD	SMD_WM	WM	XSLJZD_WM
BXXD	0
BXXD_WM	28048.32 (0, 24195406220047416)	0
CQWD	0 (0, 69857.01)	0 (0, 1321.29)	0
JPXZD	22986750.89 (0.07, 3480782610051639)	822.3 (0, 114613769790857)	582462249573.32 (4165.62, 86824668158199087104)	0
SMD_WM	772.69 (0, 202805460193874)	0.03 (0, 1605419615413.43)	19391679.88 (0, 6739519315925827584)	0 (0, 1354996.37)	0
WM	0 (0, 0)	0 (0, 0)	0 (0, 7.5)	0 (0, 0)	0 (0, 0)	0
XSLJZD_WM	14792825.45 (0, 3.68830686229498e + 20)	543.92 (0, 1313792551296612864)	397907647799.45 (0.02, 1.01862834805861e + 25)	0.66 (0, 3321105849542.14)	20391.36 (0, 22295919254655209472)	205575165013649344 (528058.51, 1.00959763024414e + 29)	0
ZSXPD	0 (0, 532.37)	0 (0, 7.77)	0 (0, 14795237.56)	0 (0, 0)	0 (0, 116.31)	2297.17 (0, 22820407856.58)	0 (0, 0.32)
Gastric emptying time	BXXD	BXXD_WM	CQWD	CSLJD	CSLJD_WM	JPXZD	SMD_WM
BXXD	0
BXXD_WM	3.31 (1.45, 7.77)	0
CQWD	5.57 (2.29, 13.92)	1.68 (0.79, 3.6)	0
CSLJD	12.15 (4.95, 29.89)	3.66 (1.69, 7.79)	2.18 (0.94, 4.96)	0
CSLJD_WM	12.34 (4.61, 33.56)	3.73 (1.56, 8.86)	2.21 (0.87, 5.6)	1.02 (0.4, 2.59)	0
JPXZD	0.9 (0.39, 2.11)	0.27 (0.14, 0.54)	0.16 (0.08, 0.34)	0.07 (0.03, 0.16)	0.07 (0.03, 0.17)	0
SMD_WM	0.99 (0.31, 3.2)	0.3 (0.1, 0.86)	0.18 (0.06, 0.54)	0.08 (0.03, 0.25)	0.08 (0.02, 0.26)	1.11 (0.38, 3.17)	0
WM	0.78 (0.4, 1.56)	0.24 (0.14, 0.38)	0.14 (0.08, 0.25)	0.06 (0.04, 0.12)	0.06 (0.03, 0.13)	0.87 (0.53, 1.41)	0.79 (0.31, 2.02)
XSLJZD	1.52 (0.62, 3.89)	0.46 (0.21, 1.01)	0.27 (0.12, 0.64)	0.13 (0.05, 0.3)	0.12 (0.05, 0.32)	1.69 (0.78, 3.74)	1.53 (0.5, 4.78)
Emptying rate	BXXD	CQWD	SMD_WM	WM	XSLJZD_WM
BXXD	0
CQWD	69.8 (0.15, 32653.33)	0
SMD_WM	0.25 (0, 358.08)	0 (0, 3.64)	0
WM	845.68 (7.55, 83742.05)	11.9 (0.2, 662.69)	3299.5 (11.8, 939381.79)	0
XSLJZD_WM	0.04 (0, 69.4)	0 (0, 0.68)	0.14 (0, 547.9)	0 (0, 0.02)	0
Adverse drug event	BXXD	BXXD_WM	CQWD	CSLJD	CSLJD_WM	SMD	SMD_WM
BXXD	1
BXXD_WM	52414822144496.4 (5.15, 4.030355125387e + 40)	1
CQWD	523486623214299 (44.52, 4.99143462215951e + 41)	9.46 (0.22, 820)	1
CSLJD	2.1013167745814e + 21 (68867.54, 6.94805069595938e + 49)	5570723.63 (10.18, 65917394402402795520)	546167.92 (0.79, 6291215618954215424)	1
CSLJD_WM	903925158662983 (64.85, 7.24389664845627e + 41)	16.04 (0.14, 2989.89)	1.66 (0.01, 331.36)	0 (0, 3.21)	1
SMD	87868125051078.8 (8.79, 6.46520330928223e + 40)	1.58 (0.07, 46.22)	0.17 (0, 5.2)	0 (0, 0.14)	0.1 (0, 9.11)	1
SMD_WM	92995980732601.7 (6.45, 7.01779753944577e + 40)	1.68 (0.02, 180.95)	0.18 (0, 19.11)	0 (0, 0.26)	0.1 (0, 26.32)	1.05 (0.01, 72.95)	1
WM	54754719159198.7 (6.18, 4.32688099919118e + 40)	1.01 (0.07, 14.35)	0.11 (0, 1.76)	0 (0, 0.07)	0.06 (0, 3.34)	0.64 (0.08, 4.09)	0.6 (0.01, 27.12)
XSLJZD	138602669761684 (13.39, 1.24283951732813e + 41)	2.63 (0.06, 124.69)	0.28 (0, 13.6)	0 (0, 0.28)	0.17 (0, 20.87)	1.65 (0.06, 46.29)	1.56 (0.01, 176)
XSLJZD_WM	2.292622716453e + 27 (1041432.11, 2.95058492834921e + 63)	681629044495.03 (13.68, 1.1410582712159e + 37)	63891194824.14 (1.24, 1.1687385549262e + 36)	69412.73 (0, 1.68323760596052e + 30)	40072042129.9 (0.6, 8.14243889280231e + 35)	419783352848.06 (9.15, 6.85444195823832e + 36)	419971257349.63 (6.35, 7.28909075697952e + 36)
ZSXPD	1.33392510385293e + 29 (3556788.54, 2.79172392054822e + 64)	25171485790455 (76.21, 3.26348786128855e + 38)	2361108310720.74 (6.5, 3.27810997427274e + 37)	1039292.85 (0, 8.27654798676685e + 30)	1488785454440.43 (3.09, 2.01068712178454e + 37)	15678668377271.4 (48.99, 1.96838317351027e + 38)	14704293429199.2 (32.62, 2.04193370876875e + 38)

MOT: Motilin; SS: Somatostatin; GAS: Gastrin; WM Western medicine; WM: Western medicine; BXXD: Banxia Xiexin Decoction; XSLJZD: Xiangshaliujunzi Decoction; SMD: Simo decoction; ZSXPD: ZhiShiXiaoPi decoction; CSLJD: Chaishaoliujun Decoction; CQWD: Chaiqin-Wendan Decoction; JPXZD: Jianpi Xiaozhi Decoction.