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©The Author(s) 2023.
World J Diabetes. Mar 15, 2023; 14(3): 147-158
Published online Mar 15, 2023. doi: 10.4239/wjd.v14.i3.147
Published online Mar 15, 2023. doi: 10.4239/wjd.v14.i3.147
Ref. | Type of study | Number of participants | Evidence for T2DM risk |
Vinceti et al[35], 2021 | Dose-response meta-analysis | - | Non-linear dose-response association. Dramatically increase from 80 μg of daily Se intake and above |
Wang et al[36], 2016 | Dose-response meta-analysis | - | Non-linear dose-response association with T2DM at low and high Se concentrations |
Duntas and Benvenga[37], 2015; Rocourt and Cheng[22], 2013 | Reviews | - | U-shaped risk response. An excess of Se promotes hyperinsulinemia, hyperglycemia and hyperlipidemia |
Rayman and Stranges[38], 2013 | Review | - | Increased selenoprotein levels in T2DM patients were reduced by the characteristic inflammatory response of T2DM |
Wang et al[39], 2017 | Cross-sectional study | 2420 participants | Negative associations were found between Se dose and insulin resistance |
Wongdokmai et al[40], 2021 | Cross-sectional study | 655 men | Abnormal metabolism in adipocytes by excessive release of fatty acids and/or hormones |
Vinceti et al[41], 2021 | Prospective study | 24325 participants | High Se intake increased the risk of hospitalization for T2DM |
Galan-Chilet et al[42], 2017 | Cross-sectional study | 1452 participants | Positive association between plasma Se with prevalent and incident diabetes |
Hoque and Shi[43], 2022 | Cross-sectional study | 18932 participants | Positively associated with diabetes but inversely associated with all-cause mortality |
Faghihi et al[44], 2014 | 3 mo | 60 T2DM patients | Se supplementation in T2DM patients with deficient Se levels resulted in adverse effects on blood glucose homeostasis |
- Citation: Casanova P, Monleon D. Role of selenium in type 2 diabetes, insulin resistance and insulin secretion. World J Diabetes 2023; 14(3): 147-158
- URL: https://www.wjgnet.com/1948-9358/full/v14/i3/147.htm
- DOI: https://dx.doi.org/10.4239/wjd.v14.i3.147