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©The Author(s) 2023.
World J Diabetes. Mar 15, 2023; 14(3): 147-158
Published online Mar 15, 2023. doi: 10.4239/wjd.v14.i3.147
Published online Mar 15, 2023. doi: 10.4239/wjd.v14.i3.147
Ref. | Type of study | Number of participants | Effects on Se intake |
Hu et al[16], 2021 | Longitudinal study (6 mo) | 90 with HT; 36 healthy subjects | Reductions in thyroid autoantibodies and thyroid-stimulating hormone levels in HT patients |
Karimi and Omrani[17], 2019 | Longitudinal study (3 mo) | 102 with AIT | Decreased antithyroid peroxidase antibody levels |
Karunasinghe et al[18], 2016 | Longitudinal study (6 mo) | 572 males | Improved leukocyte DNA integrity through increased homeostatic apoptosis when folate intake levels were low and methionine intake levels were high |
Kočan et al[19] 2014 | Longitudinal study (6 d) | 65 septic patients | Improvement of patients with acute lung injury and elevated oxidative stress |
Guo et al[20], 2019 | Longitudinal study (21 d) | 76 severe septic patients | Neutral effect |
Vinceti et al[21], 2018 | Review | - | Se had no effect in preventing cancer overall, including in patients with low Se levels |
Rocourt and Cheng[22], 2013 | Review | - | Supplementing Se to people with Se deficiency improved cancer prevention due to elimination of such deficiency |
Radomska et al[23], 2021 | Review | - | Se species as coadjuvant agents in cancer treatment due to their lower toxicity, higher selectivity and efficacy in inducing cell apoptosis |
Wu et al[14], 2018 | Cross-sectional study | 8011 participants | Higher incidence of hypertension in the group with higher serum Se concentration |
Xie et al[24], 2021 | Longitudinal study (20 yr) | 10025 participants | Protective factor for blood pressure in low-Se regions |
Rayman et al[25], 2011 | Longitudinal study (6 mo) | 501 people aged 60 yr to 74 yr | Se supplementation decreased total and non-HDL cholesterol |
Chen et al[26], 2015 | Longitudinal study (7 yr) | 2000 aged 65 and older | Decrease in total cholesterol and an increase in HDL in relation with increasing Se |
González-Estecha et al[27], 2017 | Cross-sectional study | 372 participants | Positive association of Se with total and LDL cholesterol |
Fülöp et al[28], 2013 | Study population | 81 hyperlipidemic patients; 43 healthy volunteers | Higher Se levels in hyperlipidemic patients |
Park and Seo[29], 2017 | Cross-sectional study | 501 participants | Decreased lipid dysregulation caused by elevated toenail levels of mercury |
Berger et al[30], 2008 | Longitudinal study (5 d) | 2000 cardiac surgery or major trauma or subarachnoid hemorrhage patients | Correction of initial alterations and restoration of antioxidant defenses |
Fink and Busch[31], 2018 | Longitudinal study (24 h) | 28 resuscitated patients | Improvement in neurological outcome and survival rate with early Se treatment in patients after cardiopulmonary resuscitation |
Colangelo et al[32], 2014 | Study population | 5115 participants | High Se levels were associated with a greater probability of having depressive symptoms |
Czernichow et al[33], 2009 | Longitudinal study (7.5 yr) | 5220 participants | No benefit or adverse effect of multiple antioxidant supplementation on the incidence of metabolic syndrome |
Wang et al[34], 2021 | Cross-sectional study | 3827 participants | Only positive associations when serum Se level > 130 μg/L in patients with NAFLD |
- Citation: Casanova P, Monleon D. Role of selenium in type 2 diabetes, insulin resistance and insulin secretion. World J Diabetes 2023; 14(3): 147-158
- URL: https://www.wjgnet.com/1948-9358/full/v14/i3/147.htm
- DOI: https://dx.doi.org/10.4239/wjd.v14.i3.147