Atorvastatin ameliorated myocardial fibrosis in db/db mice by inhibiting oxidative stress and modulating macrophage polarization

Figure 2 Histological changes in the myocardium. A: Hematoxylin and eosin staining was performed for each group. db/db mice that received daily oral gavage of sterilized water (DM group) had disorganized and broken myocardial fibers and irregular nuclei, which were relieved in db/db mice by daily oral gavage of 10 mg/kg/d atorvastatin (DM + ATO) or in db/db mice by daily oral gavage of 200 mg/kg metformin (DM + MET) group, especially in the DM + ATO group; B: Masson staining was performed for each group. DM group displayed deposition of collagen in the myocardial interstitium, which was relieved in the DM + ATO or DM + MET group, especially the DM + ATO group. Scale bar, 100 μm. DM: db/db mice received daily oral gavage of sterilized water; DM + ATO: db/db mice received daily oral gavage of 10 mg/kg/d atorvastatin; DM + MET: db/db mice received daily oral gavage of 200 mg/kg metformin; CON: C57BL/6 mice; H&E: Hematoxylin and eosin staining.