Genetic perspectives on childhood monogenic diabetes: Diagnosis, management, and future directions

Figure 2 The ATP-sensitive potassium channel exhibits a simple structural composition. A: The Kir6.x subunit consists of two transmembrane regions (TM1 and TM2) linked by a pore-forming area known as H5. The SURx subunit consists of three domains, including TMD0 with five transmembrane sections and TMD1 and TMD2 with six transmembrane regions each. The intracellular localization of the nucleotide-binding domains (NBD1 and NBD2) has been observed. The only distinction between SUR2A and SUR2B resides in their C-terminal end (C42); B: The functioning ATP-sensitive potassium channel comprises four Kir6.x subunits and four SURx subunits. Citation: Clement A, Guo S, Jansen-Olesen I, Christensen SL. ATP-Sensitive Potassium Channels in Migraine: Translational Findings and Therapeutic Potential. Cells 2022; 11. Copyright ©The MDPI. Published by MDPI.